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Cisplatin mouse models : treatment, toxicity and translatability
ID
Perše, Martina
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(4,22 MB)
MD5: AA398455B03B374A9138CCA842356611
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2227-9059/9/10/1406
Galerija slik
Izvleček
Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. However, despite numerous promising results, no significant improvement in treatment outcome has been achieved in humans. There are many drawbacks in the currently used cisplatin protocols in mice. In the paper, the most characterized cisplatin protocols are summarized together with weaknesses that need to be improved in future studies, including hydration and supportive care. As demonstrated, mice respond to cisplatin treatment in similar ways to humans. The paper thus aims to illustrate the complexity of cisplatin side effects (nephrotoxicity, gastrointestinal toxicity, neurotoxicity, ototoxicity and myelotoxicity) and the interconnectedness and interdependence of pathomechanisms among tissues and organs in a dose- and time-dependent manner. The paper offers knowledge that can help design future studies more efficiently and interpret study outcomes more critically. If we want to understand molecular mechanisms and find therapeutic agents that would have a potential benefit in clinics, we need to change our approach and start to treat animals as patients and not as tools.
Jezik:
Angleški jezik
Ključne besede:
cisplatin
,
toxicity
,
mouse model
,
kidney
,
gut
,
nerve system
,
mouse
,
treatment
,
tumors
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
28 str.
Številčenje:
Vol. 9, iss. 10, art. 1406
PID:
20.500.12556/RUL-136268
UDK:
616.1
ISSN pri članku:
2227-9059
DOI:
10.3390/biomedicines9101406
COBISS.SI-ID:
80342531
Datum objave v RUL:
21.04.2022
Število ogledov:
668
Število prenosov:
89
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Biomedicines
Skrajšan naslov:
Biomedicines
Založnik:
MDPI AG
ISSN:
2227-9059
COBISS.SI-ID:
523006745
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
07.10.2021
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
cisplatin
,
strupenost
,
model miške
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0054
Naslov:
Patologija in molekularna genetika
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