Vaš brskalnik ne omogoča JavaScript!
JavaScript je nujen za pravilno delovanje teh spletnih strani. Omogočite JavaScript ali pa uporabite sodobnejši brskalnik.
Nacionalni portal odprte znanosti
Odprta znanost
DiKUL
slv
|
eng
Iskanje
Brskanje
Novo v RUL
Kaj je RUL
V številkah
Pomoč
Prijava
Plectin in the central nervous system and a putative role in brain astrocytes
ID
Potokar, Maja
(
Avtor
),
ID
Jorgačevski, Jernej
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,38 MB)
MD5: 36F3FF5E0E9D72FB1B536654E96623CF
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2073-4409/10/9/2353
Galerija slik
Izvleček
Plectin, a high-molecular-mass cytolinker, is abundantly expressed in the central nervous system (CNS). Currently, a limited amount of data about plectin in the CNS prevents us from seeing the complete picture of how plectin affects the functioning of the CNS as a whole. Yet, by analogy to its role in other tissues, it is anticipated that, in the CNS, plectin also functions as the key cytoskeleton interlinking molecule. Thus, it is likely involved in signalling processes, thereby affecting numerous fundamental functions in the brain and spinal cord. Versatile direct and indirect interactions of plectin with cytoskeletal filaments and enzymes in the cells of the CNS in normal physiological and in pathologic conditions remain to be fully addressed. Several pathologies of the CNS related to plectin have been discovered in patients with plectinopathies. However, in view of plectin as an integrator of a cohesive mesh of cellular proteins, it is important that the role of plectin is also considered in other CNS pathologies. This review summarizes the current knowledge of plectin in the CNS, focusing on plectin isoforms that have been detected in the CNS, along with its expression profile and distribution alongside diverse cytoskeleton filaments in CNS cell types. Considering that the bidirectional communication between neurons and glial cells, especially astrocytes, is crucial for proper functioning of the CNS, we place particular emphasis on the known roles of plectin in neurons, and we propose possible roles of plectin in astrocytes.
Jezik:
Angleški jezik
Ključne besede:
plectin
,
central nervous system
,
astrocytes
,
glia
,
neurons
,
intermediate filaments
,
microtubules
,
actin filaments
,
cytolinker proteins
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
17 str.
Številčenje:
Vol. 10, iss. 9, art. 2353
PID:
20.500.12556/RUL-136141
UDK:
616-092
ISSN pri članku:
2073-4409
DOI:
10.3390/cells10092353
COBISS.SI-ID:
76345603
Datum objave v RUL:
13.04.2022
Število ogledov:
1427
Število prenosov:
88
Metapodatki:
Citiraj gradivo
Navadno besedilo
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Kopiraj citat
Objavi na:
Gradivo je del revije
Naslov:
Cells
Skrajšan naslov:
Cells
Založnik:
MDPI
ISSN:
2073-4409
COBISS.SI-ID:
519958809
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
08.09.2021
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
plektin
,
centralni živčni sistem
,
astrociti
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0310
Naslov:
Celična fiziologija
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
J3-9266
Naslov:
Uravnavanje fuzijske pore in motnje skladiščenja v lizosomih
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
J3-7605
Naslov:
Nanofiziologija eksocitoze v zdravih in bolezenskih razmerah
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
COST
Številka projekta:
CA15214
Akronim:
EuroCellNet
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
CipKeBip
Podobna dela
Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:
Nazaj