Therapeutic potential of polyphenols in amyotrophic lateral sclerosis and frontotemporal dementia

Novak, Valentina (avtor), Rogelj, Boris (avtor), Župunski, Vera (avtor)

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are severe neurodegenerative disorders that belong to a common disease spectrum. The molecular and cellular aetiology of the spectrum is a highly complex encompassing dysfunction in many processes, including mitochondrial dysfunction and oxidative stress. There is a paucity of treatment options aside from therapies with subtle effects on the post diagnostic lifespan and symptom management. This presents great interest and necessity for the discovery and development of new compounds and therapies with beneficial effects on the disease. Polyphenols are secondary metabolites found in plant-based foods and are well known for their antioxidant activity. Recent research suggests that they also have a diverse array of neuroprotective functions that could lead to better treatments for neurodegenerative diseases. We present an overview of the effects of various polyphenols in cell line and animal models of ALS/FTD. Furthermore, possible mechanisms behind actions of the most researched compounds (resveratrol, curcumin and green tea catechins) are discussed.

• Jezik: Angleški jezik
• Ključne besede: ALS, EGCG, FTD, catechin, curcumin, neurodegeneration, polyphenols, resveratrol
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 15 str.
• Številčenje: Vol. 10, iss. 8, art. 1328
• PID: 20.500.12556/RUL-135952
• UDK: 577:616.8
• ISSN pri članku: 2076-3921
• DOI: 10.3390/antiox10081328
• COBISS.SI-ID: 75095555
• Datum objave v RUL: 04.04.2022

Gradivo je del revije

• Naslov: Antioxidants
• Skrajšan naslov: Antioxidants
• Založnik: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 23.08.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: ALS, EGCG, FTD, katehin, kurkumin, nevrodegeneracija, polifenoli, resveratrol