Legionella pneumophila—epidemiology and characterization of clinical isolates, Slovenia, 2006–2020

Keše, Darja (avtor), Obreza, Aljoša (avtor), Rojko, Tereza (avtor), Cerar Kišek, Tjaša (avtor)

Legionella pneumophila is the causative agent of severe Legionnaires’ disease (LD). Although an increasing number of LD cases have been observed, published data from Slovenia are very limited and data on molecular epidemiology are even scarcer. The present retrospective study (2006–2020) reports the results of the microbiological diagnosis of LD, as well as the epidemiology and characterization of the Legionella clinical isolates. We tested urine samples from 15,540 patients with pneumonia symptoms for L. pneumophila infection by urine antigen test, of which 717 (4.6%) tested positive. Isolation of L. pneumophila was successfully performed from 88 clinical specimens, with 82 (93.2%) being identified as L. pneumophila sg 1 and six (6.8%) as L. pneumophila sg 2–14. Sequence-based typing (SBT) identified 33 different sequence types (STs), the most frequent being ST1 and ST23. Sequence type 1 mainly comprised isolates belonging to the Philadelphia subgroup, and ST23 mostly to Allentown/France. The standard SBT scheme, as well as Dresden phenotyping for L. pneumophila, presented a high diversity among isolates.

• Jezik: Angleški jezik
• Ključne besede: Legionnaires' disease, diagnosis, epidemiology, Legionella pneumophila typing, cultivation
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 11 str.
• Številčenje: Vol. 11, iss. 7, art. 1201
• PID: 20.500.12556/RUL-135752
• UDK: 616.9
• ISSN pri članku: 2075-4418
• DOI: 10.3390/diagnostics11071201
• COBISS.SI-ID: 69395715
• Datum objave v RUL: 30.03.2022

Gradivo je del revije

• Naslov: Diagnostics
• Skrajšan naslov: Diagnostics
• Založnik: MDPI AG
• ISSN: 2075-4418
• COBISS.SI-ID: 519963673

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 02.07.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: legionarska bolezen, diagnoza, epidemiologija

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0083
• Naslov: Odnosi parazitskega obstajanja