Targeted cancer therapy using compounds activated by light

Dunkel, Petra (avtor), Ilaš, Janez (avtor)

Cancer chemotherapy is affected by a modest selectivity and toxic side effects of pharmacological interventions. Among novel approaches to overcome this limitation and to bring to therapy more potent and selective agents is the use of light for selective activation of anticancer compounds. In this review, we focus on the anticancer applications of two light-activated approaches still in the experimental phase: photoremovable protecting groups (''photocages'') and photoswitches. We describe the structural considerations behind the development of novel compounds and the plethora of assays used to confirm whether the photochemical and pharmacological properties are meeting the stringent criteria for an efficient in vivo light-dependent activation. Despite its immense potential, light activation brings many challenges, and the complexity of the task is very demanding. Currently, we are still deeply in the phase of pharmacological tools, but the vivid research and rapid development bring the light of hope for potential clinical use.

• Jezik: Angleški jezik
• Ključne besede: photocages, photoswitches, photopharmacology, light-activatable materials, photoresponsive drug delivery systems, azobenzenes
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 49 str.
• Številčenje: Vol. 13, iss. 13, art. 3237
• PID: 20.500.12556/RUL-135435
• UDK: 615.015.14
• ISSN pri članku: 2072-6694
• DOI: 10.3390/cancers13133237
• COBISS.SI-ID: 69036803
• Datum objave v RUL: 15.03.2022

Gradivo je del revije

• Naslov: Cancers
• Skrajšan naslov: Cancers
• Založnik: MDPI
• ISSN: 2072-6694
• COBISS.SI-ID: 517914137

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.07.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: azobenzeni, fotostikala, svetlobno aktivirani materiali, fotoodzivni dostavni sistemi, fotofarmakologija, dostavni sistemi, fotokemijske reakcije, rak