Vitamin A and retinoids in bladder cancer chemoprevention and treatment : a narrative review of current evidence, challenges and future prospects

Tratnjek, Larisa (avtor), Jeruc, Jera (avtor), Romih, Rok (avtor), Zupančič, Daša (avtor)

Bladder cancer (BC) is the tenth most common cancer worldwide with a high recurrence rate, morbidity and mortality. Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC risk. In addition, retinoids, natural and synthetic derivatives of vitamin A, are intensively studied in cancer research due to their antioxidant properties and their ability to regulate cell growth, differentiation, and apoptosis. Findings from in vivo and in vitro models of BC show great potential for the use of retinoids in the chemoprevention and treatment of BC. However, translation to the clinical practice is limited. In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets.

• Jezik: Angleški jezik
• Ključne besede: bladder cancer, vitamin A, retinoic acid signalling, retinoids, chemoprevention, treatment, experimental bladder cancer models, clinical trials, delivery systems, novel targets
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 19 str.
• Številčenje: Vol. 22, iss. 7, art. 3510
• PID: 20.500.12556/RUL-135197
• UDK: 617.7
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms22073510
• COBISS.SI-ID: 57932035
• Datum objave v RUL: 28.02.2022

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.04.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: rak mehurja, vitamin A, signalizacija retinojske kisline