Polynuclear silver(I) complex with thianthrene : structural characterization, antimicrobial activity and interaction with biomolecules

Ašanin, Darko P. (avtor), Andrejević, Tina P. (avtor), Skaro-Bogojevic, Sanja (avtor), Stevanović, Nevena Lj. (avtor), Aleksić, Ivana (avtor), Milivojević, Dušan (avtor), Perdih, Franc (avtor), Turel, Iztok (avtor), Djuran, Miloš I. (avtor), Glišić, Biljana Đ. (avtor)

New silver(I) complex with thianthrene (tia), [Ag(NO$_3$)(tia)(H$_2$O)]$_n$, was synthesized by the reaction of AgNO$_3$ with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO$_3$)(tia)(H$_2$O)]$_n$ with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids.

• Jezik: Angleški jezik
• Ključne besede: silver(I) complexes, thianthrene, antimicrobial activity, DNA/BSA interaction
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.08 - Objavljeni znanstveni prispevek na konferenci
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 7 str.
• Številčenje: Vol. 67, iss. 1, art. 4
• PID: 20.500.12556/RUL-134980
• UDK: 546.57
• ISSN pri članku: 2504-3900
• DOI: 10.3390/ASEC2020-07534
• COBISS.SI-ID: 44168195
• Datum objave v RUL: 16.02.2022

Gradivo je del revije

• Naslov: Proceedings
• Skrajšan naslov: Proceedings
• Založnik: MDPI
• ISSN: 2504-3900
• COBISS.SI-ID: 42487341

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 30.11.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: srebro, srebrovi kompleksi, protimikrobno delovanje, interakcije z biomolekulami