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Determining the molecular background of endometrial receptivity in adenomyosis
ID Prašnikar, Erika (Author), ID Kunej, Tanja (Author), ID Repnik, Katja (Author), ID Potočnik, Uroš (Author), ID Knez, Jure (Author), ID Kovačič, Borut (Author)

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Abstract
Background: Adenomyosis is a gynaecological condition with limited evidence of negative impact to endometrial receptivity. It is commonly associated with endometriosis, which has been shown to alter endometrial expression patterns. Therefore, the candidate genes identified in endometriosis could serve as a source to study endometrial function in adenomyosis. Methods: Transcripts/proteins associated with endometrial receptivity in women with adenomyosis or endometriosis and healthy women were obtained from publications and their nomenclature was adopted according to the HUGO Gene Nomenclature Committee (HGNC). Retrieved genes were analysed for enriched pathways using Cytoscape/Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Reactome tools to prioritise candidates for endometrial receptivity. These were used for validation on women with (n = 9) and without (n = 13) adenomyosis. Results: Functional enrichment analysis of 173, 42 and 151 genes associated with endometriosis, adenomyosis and healthy women, respectively, revealed signalling by interleukins and interleukin-4 and interleukin-13 signalling pathways, from which annotated LIF, JUNB, IL6, FOS, IL10 and SOCS3 were prioritised. Selected genes showed downregulated expression levels in adenomyosis compared to the control group, but without statistical significance. Conclusion: This is the first integrative study providing putative candidate genes and pathways characterising endometrial receptivity in women with adenomyosis in comparison to healthy women and women with endometriosis.

Language:English
Keywords:candidate genes, endometrial receptivity, gene set enrichment analysis (GSEA), multi-omics, protein-protein interaction network (PPIN), adenomyosis, endometriosis, gene expression, genetic association studies
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:BF - Biotechnical Faculty
Publication status:Published
Publication version:Version of Record
Year:2020
Number of pages:25 str.
Numbering:Vol. 10, iss. 9, art. 1311
PID:20.500.12556/RUL-134656 This link opens in a new window
UDC:618.14-002
ISSN on article:2218-273X
DOI:10.3390/biom10091311 This link opens in a new window
COBISS.SI-ID:28211459 This link opens in a new window
Publication date in RUL:24.01.2022
Views:1457
Downloads:167
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Record is a part of a journal

Title:Biomolecules
Shortened title:Biomolecules
Publisher:MDPI
ISSN:2218-273X
COBISS.SI-ID:519952921 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:11.09.2020

Secondary language

Language:Slovenian
Keywords:endometrioza, genetske asociacijske študije, gensko izražanje, adenomioza

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P3-0327
Name:Reprodukcija človeka - laboratorijski in eksperimentalni vidiki

Funder:ARRS - Slovenian Research Agency
Project number:P4-0220
Name:Primerjalna genomika in genomska biodiverziteta

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