20.500.12556/RUL-134656 Determining the molecular background of endometrial receptivity in adenomyosis Background: Adenomyosis is a gynaecological condition with limited evidence of negative impact to endometrial receptivity. It is commonly associated with endometriosis, which has been shown to alter endometrial expression patterns. Therefore, the candidate genes identified in endometriosis could serve as a source to study endometrial function in adenomyosis. Methods: Transcripts/proteins associated with endometrial receptivity in women with adenomyosis or endometriosis and healthy women were obtained from publications and their nomenclature was adopted according to the HUGO Gene Nomenclature Committee (HGNC). Retrieved genes were analysed for enriched pathways using Cytoscape/Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Reactome tools to prioritise candidates for endometrial receptivity. These were used for validation on women with (n = 9) and without (n = 13) adenomyosis. Results: Functional enrichment analysis of 173, 42 and 151 genes associated with endometriosis, adenomyosis and healthy women, respectively, revealed signalling by interleukins and interleukin-4 and interleukin-13 signalling pathways, from which annotated LIF, JUNB, IL6, FOS, IL10 and SOCS3 were prioritised. Selected genes showed downregulated expression levels in adenomyosis compared to the control group, but without statistical significance. Conclusion: This is the first integrative study providing putative candidate genes and pathways characterising endometrial receptivity in women with adenomyosis in comparison to healthy women and women with endometriosis. candidate genes endometrial receptivity gene set enrichment analysis (GSEA) multi-omics protein-protein interaction network (PPIN) adenomyosis endometriosis gene expression genetic association studies endometrioza genetske asociacijske študije gensko izražanje adenomioza true false true Angleški jezik Slovenski jezik Članek v reviji 2022-01-24 10:40:02 2022-01-24 10:40:04 2022-09-13 03:56:22 0000-00-00 00:00:00 2020 0 0 25 str. iss. 9, art. 1311 Vol. 10 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.14-002 2218-273X 10.3390/biom10091311 28211459 RAZ_Prasnikar_Erika_2020.pdf RAZ_Prasnikar_Erika_2020.pdf 1 FE6CA367C8E02F2D14EE771228E00B16 c119236ebfb730785c6db7025d58103d109e129a9db1eb55383a548ecd525678 b3990c75-7cf9-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153200 https://www.mdpi.com/2218-273X/10/9/1311 1 68e77c48-7cf9-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153198 Biotehniška fakulteta 0 0 0