Membrane curvature, trans-membrane area asymmetry, budding, fission and organelle geometry

Mironov, Alexander A. (author), Mironov, Anna (author), Derganc, Jure (author), Beznoussenko, Galina V. (author)

In biology, the modern scientific fashion is to mostly study proteins. Much less attention is paid to lipids. However, lipids themselves are extremely important for the formation and functioning of cellular membrane organelles. Here, the role of the geometry of the lipid bilayer in regulation of organelle shape is analyzed. It is proposed that during rapid shape transition, the number of lipid heads and their size (i.e., due to the change in lipid head charge) inside lipid leaflets modulates the geometrical properties of organelles, in particular their membrane curvature. Insertion of proteins into a lipid bilayer and the shape of protein trans-membrane domains also affect the trans-membrane asymmetry between surface areas of luminal and cytosol leaflets of the membrane. In the cases where lipid molecules with a specific shape are not predominant, the shape of lipids (cylindrical, conical, or wedge-like) is less important for the regulation of membrane curvature, due to the flexibility of their acyl chains and their high ability to diffuse.

• Language: English
• Keywords: mitochondria fusion, trans-membrane area asymmetry, membrane fission, budding, COP, caveola, endosome, filopodia, Golgi, nuclear envelope
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 19 str.
• Numbering: Vol. 21, iss. 20, art. 7594
• PID: 20.500.12556/RUL-134407
• UDC: 577
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms21207594
• COBISS.SI-ID: 72994307
• Publication date in RUL: 13.01.2022

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 14.10.2020

Secondary language

• Language: Slovenian
• Keywords: zlitje mitohondrijev, asimetrija transmembranskega območja, cepitev membrane