20.500.12556/RUL-134407 Membrane curvature, trans-membrane area asymmetry, budding, fission and organelle geometry In biology, the modern scientific fashion is to mostly study proteins. Much less attention is paid to lipids. However, lipids themselves are extremely important for the formation and functioning of cellular membrane organelles. Here, the role of the geometry of the lipid bilayer in regulation of organelle shape is analyzed. It is proposed that during rapid shape transition, the number of lipid heads and their size (i.e., due to the change in lipid head charge) inside lipid leaflets modulates the geometrical properties of organelles, in particular their membrane curvature. Insertion of proteins into a lipid bilayer and the shape of protein trans-membrane domains also affect the trans-membrane asymmetry between surface areas of luminal and cytosol leaflets of the membrane. In the cases where lipid molecules with a specific shape are not predominant, the shape of lipids (cylindrical, conical, or wedge-like) is less important for the regulation of membrane curvature, due to the flexibility of their acyl chains and their high ability to diffuse. mitochondria fusion trans-membrane area asymmetry membrane fission budding COP caveola endosome filopodia Golgi nuclear envelope zlitje mitohondrijev asimetrija transmembranskega območja cepitev membrane true false true Angleški jezik Slovenski jezik Članek v reviji 2022-01-13 13:51:42 2022-01-13 13:51:43 2022-09-13 03:54:58 0000-00-00 00:00:00 2020 0 0 19 str. iss. 20, art. 7594 Vol. 21 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577 1422-0067 10.3390/ijms21207594 72994307 RAZ_Mironov_Alexander_A._2020.pdf RAZ_Mironov_Alexander_A._2020.pdf 1 0B64B5B9D26C17F2FA701D919787E147 0825120006c633211b172aef12e850566ed70fcdd1a03cca3961901f5d1fc003 cce97603-746f-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152845 https://www.mdpi.com/1422-0067/21/20/7594 1 60de4063-746f-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=152844 Medicinska fakulteta 0 0 0