Membrane curvature, trans-membrane area asymmetry, budding, fission and organelle geometry

Mironov, Alexander A. (avtor), Mironov, Anna (avtor), Derganc, Jure (avtor), Beznoussenko, Galina V. (avtor)

In biology, the modern scientific fashion is to mostly study proteins. Much less attention is paid to lipids. However, lipids themselves are extremely important for the formation and functioning of cellular membrane organelles. Here, the role of the geometry of the lipid bilayer in regulation of organelle shape is analyzed. It is proposed that during rapid shape transition, the number of lipid heads and their size (i.e., due to the change in lipid head charge) inside lipid leaflets modulates the geometrical properties of organelles, in particular their membrane curvature. Insertion of proteins into a lipid bilayer and the shape of protein trans-membrane domains also affect the trans-membrane asymmetry between surface areas of luminal and cytosol leaflets of the membrane. In the cases where lipid molecules with a specific shape are not predominant, the shape of lipids (cylindrical, conical, or wedge-like) is less important for the regulation of membrane curvature, due to the flexibility of their acyl chains and their high ability to diffuse.

• Jezik: Angleški jezik
• Ključne besede: mitochondria fusion, trans-membrane area asymmetry, membrane fission, budding, COP, caveola, endosome, filopodia, Golgi, nuclear envelope
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 19 str.
• Številčenje: Vol. 21, iss. 20, art. 7594
• PID: 20.500.12556/RUL-134407
• UDK: 577
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms21207594
• COBISS.SI-ID: 72994307
• Datum objave v RUL: 13.01.2022

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 14.10.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: zlitje mitohondrijev, asimetrija transmembranskega območja, cepitev membrane