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The diversity of intermediate filaments in astrocytes
ID Potokar, Maja (Avtor), ID Morita, Mitsuhiro (Avtor), ID Wiche, Gerhard (Avtor), ID Jorgačevski, Jernej (Avtor)

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Izvleček
Despite the remarkable complexity of the individual neuron and of neuronal circuits, it has been clear for quite a while that, in order to understand the functioning of the brain, the contribution of other cell types in the brain have to be accounted for. Among glial cells, astrocytes have multiple roles in orchestrating neuronal functions. Their communication with neurons by exchanging signaling molecules and removing molecules from extracellular space takes place at several levels and is governed by different cellular processes, supported by multiple cellular structures, including the cytoskeleton. Intermediate filaments in astrocytes are emerging as important integrators of cellular processes. Astrocytes express five types of intermediate filaments: glial fibrillary acidic protein (GFAP); vimentin; nestin; synemin; lamins. Variability, interactions with different cellular structures and the particular roles of individual intermediate filaments in astrocytes have been studied extensively in the case of GFAP and vimentin, but far less attention has been given to nestin, synemin and lamins. Similarly, the interplay between different types of cytoskeleton and the interaction between the cytoskeleton and membranous structures, which is mediated by cytolinker proteins, are understudied in astrocytes. The present review summarizes the basic properties of astrocytic intermediate filaments and of other cytoskeletal macromolecules, such as cytolinker proteins, and describes the current knowledge of their roles in normal physiological and pathological conditions.

Jezik:Angleški jezik
Ključne besede:astrocytes, intermediate filaments, vimentin, GFAP, nestin, synemin, plectin, cytolinker proteins, reactive gliosis
Vrsta gradiva:Članek v reviji
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2020
Št. strani:24 str.
Številčenje:Vol. 9, iss. 7, art. 1604
PID:20.500.12556/RUL-133823 Povezava se odpre v novem oknu
UDK:616-092
ISSN pri članku:2073-4409
DOI:10.3390/cells9071604 Povezava se odpre v novem oknu
COBISS.SI-ID:21974019 Povezava se odpre v novem oknu
Datum objave v RUL:16.12.2021
Število ogledov:770
Število prenosov:193
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Cells
Skrajšan naslov:Cells
Založnik:MDPI
ISSN:2073-4409
COBISS.SI-ID:519958809 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:02.07.2020

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:astrociti, vmesni filamenti, vimentin

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0310
Naslov:Celična fiziologija

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-7605
Naslov:Nanofiziologija eksocitoze v zdravih in bolezenskih razmerah

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-9266
Naslov:Uravnavanje fuzijske pore in motnje skladiščenja v lizosomih

Financer:Drugi - Drug financer ali več financerjev
Program financ.:JSPS KAKENHI
Številka projekta:17K07110

Financer:Drugi - Drug financer ali več financerjev
Program financ.:JSPS KAKENHI
Številka projekta:18KT0071

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:BI-JP/18-20-002

Financer:Drugi - Drug financer ali več financerjev
Program financ.:COST
Številka projekta:CA15214
Akronim:EuroCellNet

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