MicroRNA-target interaction regulatory network in Alzheimer’s disease

Turk, Aleksander (avtor), Kunej, Tanja (avtor), Peterlin, Borut (avtor)

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia; however, early diagnosis of the disease is challenging. Research suggests that biomarkers found in blood, such as microRNAs (miRNA), may be promising for AD diagnostics. Experimental data on miRNA–target interactions (MTI) associated with AD are scattered across databases and publications, thus making the identification of promising miRNA biomarkers for AD difficult. In response to this, a list of experimentally validated AD-associated MTIs was obtained from miRTarBase. Cytoscape was used to create a visual MTI network. STRING software was used for protein–protein interaction analysis and mirPath was used for pathway enrichment analysis. Several targets regulated by multiple miRNAs were identified, including: BACE1, APP, NCSTN, SP1, SIRT1, and PTEN. The miRNA with the highest numbers of interactions in the network were: miR-9, miR-16, miR-34a, miR-106a, miR-107, miR-125b, miR-146, and miR-181c. The analysis revealed seven subnetworks, representing disease modules which have a potential for further biomarker development. The obtained MTI network is not yet complete, and additional studies are needed for the comprehensive understanding of the AD-associated miRNA targetome.

• Jezik: Angleški jezik
• Ključne besede: Alzheimer’s disease, protein–protein interaction (PPI), biomarker, microRNA (miRNA), miRNA–target interaction (MTI)
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 18 str.
• Številčenje: Vol. 11, iss. 12, art. 1275
• PID: 20.500.12556/RUL-133693
• UDK: 616:575
• ISSN pri članku: 2075-4426
• DOI: 10.3390/jpm11121275
• COBISS.SI-ID: 87716611
• Datum objave v RUL: 09.12.2021

Gradivo je del revije

• Naslov: Journal of personalized medicine
• Skrajšan naslov: J. pers. med.
• Založnik: MDPI
• ISSN: 2075-4426
• COBISS.SI-ID: 31207641

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 02.12.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: medicina, Alzheimerjeva bolezen, bioinformatika, biomarkerji, genetika, miRNA, zunajcelični vezikli

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0326
• Naslov: Ginekologija in reprodukcija: genomika za personalizirano medicino

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0220
• Naslov: Primerjalna genomika in genomska biodiverziteta