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Comparative bioavailability of different coenzyme Q10 formulations in healthy elderly Individuals
ID
Pravst, Igor
(
Avtor
),
ID
Rodríguez Aguilera, Juan Carlos
(
Avtor
),
ID
Cortes Rodriguez, Ana Belen
(
Avtor
),
ID
Jazbar, Janja
(
Avtor
),
ID
Locatelli, Igor
(
Avtor
),
ID
Hristov, Hristo
(
Avtor
),
ID
Žmitek, Katja
(
Avtor
)
PDF - Predstavitvena datoteka,
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MD5: 105BF779D249D677AA4AADDF07F86F0B
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2072-6643/12/3/784
Galerija slik
Izvleček
Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65-74). The treatment was a single dose with a one-week washout period. Three different formulations containing the equivalent of 100 mg of CoQ10 were used: Q10Vital$^®$ water-soluble CoQ10 syrup (the investigational product—IP); ubiquinol capsules (the comparative product—CP); and ubiquinone capsules (the standard product—SP). Ubiquinone/ubiquinol was followed in the plasma for 48 h. An analysis of the ratio of the area under the baseline-corrected concentration curve (∆AUC$_{48}$) for total CoQ10 and a comparison to SP yielded the following: The bioavailability of CoQ10 in the IP was 2.4-fold higher (95% CI: 1.3-4.5; p = 0.002), while the bioavailability of ubiquinol (CP) was not significantly increased (1.7-fold; 95% CI: 0.9–3.1, p = 0.129). No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiquinone.
Jezik:
Angleški jezik
Ključne besede:
coenzyme Q10
,
CoQ10
,
Q10Vital$^®$
,
ubiquinone
,
ubiquinol
,
bioavailability
,
water-soluble formulations
,
the elderly
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
13 str.
Številčenje:
Vol. 12, iss. 3, art. 784
PID:
20.500.12556/RUL-133619
UDK:
577.161.6:613.292-053.88
ISSN pri članku:
2072-6643
DOI:
10.3390/nu12030784
COBISS.SI-ID:
4895089
Datum objave v RUL:
06.12.2021
Število ogledov:
743
Število prenosov:
183
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Nutrients
Skrajšan naslov:
Nutrients
Založnik:
MDPI
ISSN:
2072-6643
COBISS.SI-ID:
2948140
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
16.03.2020
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
ubikinon
,
starejši ljudje
,
prehranski dodatki
,
ubikinol
,
prehranjevanje
,
koristi prehranskih dodatkov
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0395
Naslov:
Prehrana in javno zdravje
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Valens Int. d.o.o.
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