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Comparison of a five-year survival and cancer recurrence between laparoscopically assisted and open colonic resections due to adenocarcinoma : a single centre experience
ID Janež, Jurij (Avtor), ID Škapin, Armand Dominik (Avtor)

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Izvleček
Background and objectives: When resecting colon adenocarcinoma, surgeons decide between the use of laparoscopically assisted and open surgery. Laparoscopic resection is known to have short-term benefits over an open operation. However, researchers are not as unified about the long-term findings. The aim of this research is to elaborate on five-year post-operative differences in survival and cancer recurrence between these two different approaches. Materials and methods: 74 enrolled patients were evaluated five years after a primary operation. We collected dates of deaths of deceased patients and time after operation of possible recurrences. Carcinoma staging was done by a pathologist after operation. Blood samples were taken before surgery in order to measure tumor markers (CA19-9 and CEA). Results: Survival after colonic adenocarcinoma surgery did not differ between the two different surgical approaches (p = 0.151). Recurrence of cancer was not associated with the type of operation (p = 0.532). Patients with recurrence had a 37.6 times greater hazard ratio of dying (95% CI: [12.0, 118]; p < 0.001). Advanced age adversely affected survival: patients aged < 0.001). Patients with different TNM stages did not have any statistically significant differences in survival (HR$_{II}$ = 2.49; 95% CI: [0.67, 9.30]; p$_{II}$ = 0.173) (HR$_{III}$ = 2.18; 95% CI: [0.58, 8.12]; p$_{III}$ = 0.246) or recurrence (p = 0.097). Conclusion: The obtained results suggest that laparoscopic resection of colon cancer is not inferior from an oncologic point of view and results in a similar long-term survival and disease-free interval. Recurrence of carcinoma, older age at initial operation and elevated tumor markers, above a pre-set threshold at operation, were found to be independent factors of lower survival. We believe that the obtained results will be of benefit when choosing treatment for colon adenocarcinoma.

Jezik:Angleški jezik
Ključne besede:colon cancer, survival, recurrence, surgery, laparoscopy
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2020
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:11 str.
Številčenje:Vol. 56, iss. 2, art. 93
PID:20.500.12556/RUL-133430 Povezava se odpre v novem oknu
UDK:617
ISSN pri članku:1648-9144
DOI:10.3390/medicina56020093 Povezava se odpre v novem oknu
COBISS.SI-ID:7045036 Povezava se odpre v novem oknu
Datum objave v RUL:26.11.2021
Število ogledov:148
Število prenosov:50
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Naslov:Medicina
Založnik:MDPI
ISSN:1648-9144
COBISS.SI-ID:6754623 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:24.02.2020

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