An overview of crucial dietary substances and their modes of action for prevention of neurodegenerative diseases

Pogačnik da Silva, Lea (author), Ota, Ajda (author), Poklar Ulrih, Nataša (author)

Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans.

• Language: English
• Keywords: dietary phytochemicals, endogenous substances, mitochondrial dysfunction, neurodegenerative diseases, neuroinflammation, oxidative stress, protein fibrillation
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 25 str.
• Numbering: Vol. 9, iss. 3, art. 576
• PID: 20.500.12556/RUL-133217
• UDC: 547.9:547.56:616.8
• ISSN on article: 2073-4409
• DOI: 10.3390/cells9030576
• COBISS.SI-ID: 5172856
• Publication date in RUL: 17.11.2021

Record is a part of a journal

• Title: Cells
• Shortened title: Cells
• Publisher: MDPI
• ISSN: 2073-4409
• COBISS.SI-ID: 519958809

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.03.2020

Secondary language

• Language: Slovenian
• Keywords: prehrana, živila, naravne snovi, bioaktivne spojine, fenolne spojine, polifenoli, nevroprotektivne snovi, oksidativni stres, rastlinski ekstrakti, sadje, zelenjava, zeleni čaj, kurkumin, zdravilne učinkovine, nevrodegenerativne bolezni

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0121
• Name: Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi