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An overview of crucial dietary substances and their modes of action for prevention of neurodegenerative diseases
Pogačnik, Lea (Author), Ota, Ajda (Author), Poklar Ulrih, Nataša (Author)

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Abstract
Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans.

Language:English
Keywords:dietary phytochemicals, endogenous substances, mitochondrial dysfunction, neurodegenerative diseases, neuroinflammation, oxidative stress, protein fibrillation
Work type:Article (dk_c)
Tipology:1.02 - Review Article
Organization:BF - Biotechnical Faculty
Year:2020
Number of pages:25 str.
Numbering:Vol. 9, iss. 3, art. 576
UDC:547.9:547.56:616.8
ISSN on article:2073-4409
DOI:10.3390/cells9030576 This link opens in a new window
COBISS.SI-ID:5172856 This link opens in a new window
Views:98
Downloads:26
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Record is a part of a journal

Title:Cells
Shortened title:Cells
Publisher:MDPI
ISSN:2073-4409
COBISS.SI-ID:519958809 This link opens in a new window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P4-0121
Name:Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.03.2020

Secondary language

Language:Slovenian
Keywords:prehrana, živila, naravne snovi, bioaktivne spojine, fenolne spojine, polifenoli, nevroprotektivne snovi, oksidativni stres, rastlinski ekstrakti, sadje, zelenjava, zeleni čaj, kurkumin, zdravilne učinkovine, nevrodegenerativne bolezni

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