An overview of crucial dietary substances and their modes of action for prevention of neurodegenerative diseases
ID Pogačnik da Silva, Lea (Author), ID Ota, Ajda (Author), ID Poklar Ulrih, Nataša (Author)

.pdfPDF - Presentation file, Download (1,20 MB)
MD5: CA4C5A4D89F66C1361961D97AD4981CD
URLURL - Source URL, Visit https://www.mdpi.com/2073-4409/9/3/576 This link opens in a new window

Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans.

Keywords:dietary phytochemicals, endogenous substances, mitochondrial dysfunction, neurodegenerative diseases, neuroinflammation, oxidative stress, protein fibrillation
Work type:Article
Typology:1.02 - Review Article
Organization:BF - Biotechnical Faculty
Publication status:Published
Publication version:Version of Record
Number of pages:25 str.
Numbering:Vol. 9, iss. 3, art. 576
PID:20.500.12556/RUL-133217 This link opens in a new window
ISSN on article:2073-4409
DOI:10.3390/cells9030576 This link opens in a new window
COBISS.SI-ID:5172856 This link opens in a new window
Publication date in RUL:17.11.2021
Copy citation
Share:Bookmark and Share

Record is a part of a journal

Shortened title:Cells
COBISS.SI-ID:519958809 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.03.2020

Secondary language

Keywords:prehrana, živila, naravne snovi, bioaktivne spojine, fenolne spojine, polifenoli, nevroprotektivne snovi, oksidativni stres, rastlinski ekstrakti, sadje, zelenjava, zeleni čaj, kurkumin, zdravilne učinkovine, nevrodegenerativne bolezni


Funder:ARRS - Slovenian Research Agency
Project number:P4-0121
Name:Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi

Similar documents

Similar works from RUL:
Similar works from other Slovenian collections: