20.500.12556/RUL-133217 An overview of crucial dietary substances and their modes of action for prevention of neurodegenerative diseases Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans. dietary phytochemicals endogenous substances mitochondrial dysfunction neurodegenerative diseases neuroinflammation oxidative stress protein fibrillation prehrana živila naravne snovi bioaktivne spojine fenolne spojine polifenoli nevroprotektivne snovi oksidativni stres rastlinski ekstrakti sadje zelenjava zeleni čaj kurkumin zdravilne učinkovine nevrodegenerativne bolezni true false true Angleški jezik Slovenski jezik Članek v reviji 2021-11-17 10:36:22 2021-11-17 10:36:23 2022-09-12 04:15:23 0000-00-00 00:00:00 2020 0 0 25 str. iss. 3, art. 576 Vol. 9 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.9:547.56:616.8 2073-4409 10.3390/cells9030576 5172856 RAZ_Pogacnik_Lea_2020.pdf RAZ_Pogacnik_Lea_2020.pdf 1 CA4C5A4D89F66C1361961D97AD4981CD 50cc1720f537cb8a6f4df50d9354b70075ca3cbaafed5b3428b20f71de747ac5 f48e9555-4789-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=151104 https://www.mdpi.com/2073-4409/9/3/576 1 c20244e9-4789-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=151103 Biotehniška fakulteta 0 0 0