Microwave-assisted Kabachnik-Fields reaction with amino alcohols as the amine component

Tajti, Ádám (avtor), Szatmári, Enikő (avtor), Perdih, Franc (avtor), Keglevich, G. (avtor), Bálint, Erika (avtor)

In this paper, the microwave (MW)-assisted catalyst-free and mostly solvent-free Kabachnik–Fields reaction of amino alcohols, paraformaldehyde, and various >P(O)H reagents (dialkyl phosphites, ethyl phenyl-H-phosphinate, and secondary phosphine oxides) is reported. The synthesis of N-2-hydroxyethyl-α-aminophosphonate derivatives was optimized in respect of the temperature, the reaction time, and the molar ratio of the starting materials. A few by-products were also identified. N,N-Bis(phosphinoylmethyl)amines containing a hydroxyethyl group were also prepared by the double Kabachnik–Fields reaction of ethanolamine with an excess of paraformaldehyde and secondary phosphine oxides. The crystal structure of a 2-hydroxyethyl-α-aminophosphine oxide and a bis(phosphinoylmethyl)ethanolamine was studied by X-ray analysis.

• Jezik: Angleški jezik
• Ključne besede: α-aminophosphonate derivatives, Kabachnik-Fields reaction, amino alcohols, microwave, X-ray diffraction
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2019
• Št. strani: 13 str.
• Številčenje: Vol. 24, iss. 8, art. 1640
• PID: 20.500.12556/RUL-132249
• UDK: 547.435-732
• ISSN pri članku: 1420-3049
• DOI: 10.3390/molecules24081640
• COBISS.SI-ID: 1538222531
• Datum objave v RUL: 19.10.2021

Gradivo je del revije

• Naslov: Molecules
• Skrajšan naslov: Molecules
• Založnik: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 25.04.2019

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: aminofosfonati, Kabachnik-Fieldsova reakcija, amino alkoholi, mikrovalovi, rentgenska difrakcija