Evaluation of oxidative stress parameters in dogs with brachycephalic obstructive airway syndrome before and after surgery

Erjavec, Vladimira (avtor), Vovk, Tomaž (avtor), Nemec Svete, Alenka (avtor)

Abstract Introduction: Canine brachycephalic obstructive airway syndrome (BOAS) is a conformation-related respiratory disorder of dog breeds having congenitally flattened facial and skull anatomy. The aim of the study was to determine oxidative stress parameters, the lipid peroxidation product malondialdehyde, and antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase in BOAS patients before and after surgical treatment and in healthy brachycephalic dogs. Material and Methods: Nine healthy brachycephalic dogs that had not undergone surgery and 39 BOAS patients were included in the study. The BOAS patients were classified as grade 1 (5/34), grade 2 (16/34), and grade 3 (13/34) based on the decrease in the radius of the airway in the larynx. In BOAS patients, oxidative stress parameters were determined before and two weeks after surgery, while in control dogs, blood samples were collected only on inclusion to the study. Results: All BOAS patients showed various degrees of improvement in clinical signs after surgery. Significantly lower (P < 0.05) SOD activity was found in grade 2 and 3 BOAS patients than in grade 1 patients. Two weeks after surgery, a significant (P < 0.05) increase in SOD activity in grade 2 and 3 patients was observed. Conclusion: Antioxidant enzyme SOD may play an important role in BOAS and can be used as a biomarker of antioxidant status assessment in BOAS patients.

• Jezik: Angleški jezik
• Ključne besede: brachycephalic obstructive airway syndrome, malondialdehyde, superoxide dismutase, glutathione peroxidase, oral surgery
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta ; FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Poslano v recenzijo: 30.09.2020
• Datum sprejetja članka: 07.05.2021
• Datum objave: 22.05.2021
• Leto izida: 2021
• Št. strani: Str. 201-208
• Številčenje: Vol. 65, no. 2
• PID: 20.500.12556/RUL-132095
• UDK: 636.7.09:616
• ISSN pri članku: 2450-7393
• DOI: 10.2478/jvetres-2021-0027
• COBISS.SI-ID: 64497411
• Datum objave v RUL: 12.10.2021

Gradivo je del revije

• Naslov: Journal of Veterinary Research
• Skrajšan naslov: J. Vet. Res.
• Založnik: National Veterinary Research Institute
• ISSN: 2450-7393
• COBISS.SI-ID: 4727418

Licence

• Licenca: CC BY-NC 3.0, Creative Commons Priznanje avtorstva-Nekomercialno 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by-nc/3.0/deed.sl
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• Začetek licenciranja: 22.05.2021

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P4-0053
• Naslov: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0189
• Naslov: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih