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New insights into the evolutionary and genomic landscape of molluscum contagiosum virus (MCV) based on nine MCV1 and six MCV2 complete genome sequences
Zorec, Tomaž Mark (Avtor), Kutnjak, Denis (Avtor), Hošnjak, Lea (Avtor), Kušar, Blanka (Avtor), Trčko, Katarina (Avtor), Kocjan, Boštjan (Avtor), Li, Yu (Avtor), Križmarić, Miljenko (Avtor), Miljković, Jovan (Avtor), Ravnikar, Maja (Avtor), Poljak, Mario (Avtor)

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Izvleček
Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). In comparison to MCV1, a higher degree of nucleotide sequence conservation was observed among MCV2 genomes. Large-scale recombination events were identified in two newly assembled MCV1 genomes and one MCV2 genome. One recombination event was located in a newly identified recombinant region of the viral genome, and all previously described recombinant regions were re-identified in at least one novel MCV genome. MCV genes comprising the identified recombinant segments have been previously associated with viral interference with host T-cell and NK-cell immune responses. In conclusion, the two most common MCV genotypes emerged along divergent evolutionary pathways from a common ancestor, and the differences in the heterogeneity of MCV1 and MCV2 populations may be attributed to the strictness of the constraints imposed by the host immune response.

Jezik:Angleški jezik
Ključne besede:molluscum contagiosum virus, complete genome, recombination, immune evasion, evolution, genetic landscape
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2018
Št. strani:24 str.
Številčenje:Vol. 10, iss. 11, art. 586
UDK:616.9
ISSN pri članku:1999-4915
DOI:10.3390/v10110586 Povezava se odpre v novem oknu
COBISS.SI-ID:34025433 Povezava se odpre v novem oknu
Število ogledov:67
Število prenosov:23
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Viruses
Skrajšan naslov:Viruses
Založnik:MDPI
ISSN:1999-4915
COBISS.SI-ID:517597977 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P3-0083
Naslov:Odnosi parazitskega obstajanja

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P4-0165
Naslov:Biotehnologija in sistemska biologija rastlin

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:01.11.2018

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:virus molluscum contagiosum, popolni genom, rekombinacija

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