Peptides as potential therapeutics for Alzheimer's disease
ID Ribarič, Samo (Author)

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Intracellular synthesis, folding, trafficking and degradation of proteins are controlled and integrated by proteostasis. The frequency of protein misfolding disorders in the human population, e.g., in Alzheimer's disease (AD), is increasing due to the aging population. AD treatment options are limited to symptomatic interventions that at best slow-down disease progression. The key biochemical change in AD is the excessive accumulation of per-se non-toxic and soluble amyloid peptides (Aβ(1-37/44), in the intracellular and extracellular space, that alters proteostasis and triggers Aβ modification (e.g., by reactive oxygen species (ROS)) into toxic intermediate, misfolded soluble Aβ peptides, Aβ dimers and Aβ oligomers. The toxic intermediate Aβ products aggregate into progressively less toxic and less soluble protofibrils, fibrils and senile plaques. This review focuses on peptides that inhibit toxic Aβ oligomerization, Aβ aggregation into fibrils, or stabilize Aβ peptides in non-toxic oligomers, and discusses their potential for AD treatment.

Keywords:Alzheimer's disease, amyloid β oligomers, amyloid β peptide, aggregation, amyloid β plaques, insulin, neurofibrillary tangles, tau protein, peptides, peptide therapy
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:31 str.
Numbering:Vol. 23, iss. 2, art. 283
PID:20.500.12556/RUL-131869 This link opens in a new window
ISSN on article:1420-3049
DOI:10.3390/molecules23020283 This link opens in a new window
COBISS.SI-ID:33689817 This link opens in a new window
Publication date in RUL:05.10.2021
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Shortened title:Molecules
COBISS.SI-ID:18462981 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.02.2018

Secondary language

Keywords:Alzheimerjeva bolezen, amiloidni β oligomeri, amiloidni peptid


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P3-0171
Name:Plastičnost živčevja v fizioloških in patofizioloških razmerah

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