Peptides as potential therapeutics for Alzheimer's disease

Ribarič, Samo (author)

Intracellular synthesis, folding, trafficking and degradation of proteins are controlled and integrated by proteostasis. The frequency of protein misfolding disorders in the human population, e.g., in Alzheimer's disease (AD), is increasing due to the aging population. AD treatment options are limited to symptomatic interventions that at best slow-down disease progression. The key biochemical change in AD is the excessive accumulation of per-se non-toxic and soluble amyloid peptides (Aβ(1-37/44), in the intracellular and extracellular space, that alters proteostasis and triggers Aβ modification (e.g., by reactive oxygen species (ROS)) into toxic intermediate, misfolded soluble Aβ peptides, Aβ dimers and Aβ oligomers. The toxic intermediate Aβ products aggregate into progressively less toxic and less soluble protofibrils, fibrils and senile plaques. This review focuses on peptides that inhibit toxic Aβ oligomerization, Aβ aggregation into fibrils, or stabilize Aβ peptides in non-toxic oligomers, and discusses their potential for AD treatment.

• Language: English
• Keywords: Alzheimer's disease, amyloid β oligomers, amyloid β peptide, aggregation, amyloid β plaques, insulin, neurofibrillary tangles, tau protein, peptides, peptide therapy
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2018
• Number of pages: 31 str.
• Numbering: Vol. 23, iss. 2, art. 283
• PID: 20.500.12556/RUL-131869
• UDC: 616.8
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules23020283
• COBISS.SI-ID: 33689817
• Publication date in RUL: 05.10.2021

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.02.2018

Secondary language

• Language: Slovenian
• Keywords: Alzheimerjeva bolezen, amiloidni β oligomeri, amiloidni peptid

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0171
• Name: Plastičnost živčevja v fizioloških in patofizioloških razmerah