20.500.12556/RUL-131869 Peptides as potential therapeutics for Alzheimer's disease Intracellular synthesis, folding, trafficking and degradation of proteins are controlled and integrated by proteostasis. The frequency of protein misfolding disorders in the human population, e.g., in Alzheimer's disease (AD), is increasing due to the aging population. AD treatment options are limited to symptomatic interventions that at best slow-down disease progression. The key biochemical change in AD is the excessive accumulation of per-se non-toxic and soluble amyloid peptides (Aβ(1-37/44), in the intracellular and extracellular space, that alters proteostasis and triggers Aβ modification (e.g., by reactive oxygen species (ROS)) into toxic intermediate, misfolded soluble Aβ peptides, Aβ dimers and Aβ oligomers. The toxic intermediate Aβ products aggregate into progressively less toxic and less soluble protofibrils, fibrils and senile plaques. This review focuses on peptides that inhibit toxic Aβ oligomerization, Aβ aggregation into fibrils, or stabilize Aβ peptides in non-toxic oligomers, and discusses their potential for AD treatment. Alzheimer's disease amyloid β oligomers amyloid β peptide aggregation amyloid β plaques insulin neurofibrillary tangles tau protein peptides peptide therapy Alzheimerjeva bolezen amiloidni β oligomeri amiloidni peptid true false true Angleški jezik Slovenski jezik Članek v reviji 2021-10-05 10:00:46 2021-10-05 10:00:48 2022-09-10 04:14:17 0000-00-00 00:00:00 2018 0 0 31 str. iss. 2, art. 283 Vol. 23 Jan. 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 1420-3049 10.3390/molecules23020283 33689817 RAZ_Ribaric_Samo_2018.pdf RAZ_Ribaric_Samo_2018.pdf 1 B4121759E674B4AB9D682E8B168870C0 c66e04b0bf0a7b529c645379fd6e232d59c267579079ee84bddc3b0fe572324b 60bd070d-25b2-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149297 http://www.mdpi.com/1420-3049/23/2/283 1 0f1e6169-25b2-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=149296 Medicinska fakulteta 0 0 0