A kinetic approach in the evaluation of radical-scavenging efficiency of sinapic acid and its derivatives

Martinović, Neda (author), Polak, Tomaž (author), Makuc, Damjan (author), Poklar Ulrih, Nataša (author), Abramovič, Helena (author)

A kinetic approach was used to determine the radical scavenging activities of sinapic acid and its derivatives: sinapine, 4-vinylsyringol, syringic acid, syringaldehyde, and ethyl, propyl and butyl sinapate. The responses were expressed as rates of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH$^·$) scavenging (R$_S$), superoxide radical (O$_2$$^{·−}$) scavenging (R$_{FF}$), and β-carotene bleaching in the emulsion system (R$_B$). For R$_S$ and R$_B$, the esters of sinapic acid showed the highest responses while, for R$_{FF}$, this was seen for syringic acid. The effectiveness of the selected compounds for scavenging these free radicals was also determined at a fixed endpoint. The early response parameters were demonstrated to be good discriminators in assessing differences for antioxidants with comparable fixed endpoint activity. The primary feature that ranks the kinetic data and the endpoint determinations is interpreted in terms of the mechanisms of the reactions involved in each of the assays conducted.

• Language: English
• Keywords: sinapic acid, antioxidant activity, radical scavenging kinetics, radical scavenging mechanisms
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2017
• Number of pages: 17 str.
• Numbering: Vol. 22, iss. 3, art. 375
• PID: 20.500.12556/RUL-131182
• UDC: 577.1:547.587.53
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules22030375
• COBISS.SI-ID: 4761720
• Publication date in RUL: 23.09.2021

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.03.2017

Secondary language

• Language: Slovenian
• Keywords: organske kisline, fenolne kisline, sinapinske kisline, sinapin, antioksidativna učinkovitost, DPPH, lovilci prostih radikalov

Projects

• Funder: EC - European Commission
• Funding programme: Erasmus Mundus Action 2
• Name: Basileus III

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0121
• Name: Biokemijska in biofizikalno-kemijska karakterizacija naravnih snovi