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Ostreolysin A/pleurotolysin B and equinatoxins : structure, function and pathophysiological effects of these pore-forming proteins
Frangež, Robert (Avtor), Šuput, Dušan (Avtor), Molgó, Jordi (Avtor), Benoit, Evelyne (Avtor)

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Izvleček
Acidic ostreolysin A/pleurotolysin B (OlyA/PlyB, formerly known as ostreolysin (Oly), and basic 20 kDa equinatoxins (EqTs) are cytolytic proteins isolated from the edible mushroom Pleurotus ostreatus and the sea anemone Actinia equina, respectively. Both toxins, although from different sources, share many similar biological activities: (i) colloid-osmotic shock by forming pores in cellular and artificial membranes enriched in cholesterol and sphingomyelin; (ii) increased vascular endothelial wall permeability in vivo and perivascular oedema; (iii) dose-dependent contraction of coronary vessels; (iv) haemolysis with pronounced hyperkalaemia in vivo; (v) bradycardia, myocardial ischemia and ventricular extrasystoles accompanied by progressive fall of arterial blood pressure and respiratory arrest in rodents. Both types of toxins are haemolytic within nanomolar range concentrations, and it seems that hyperkalaemia plays an important role in toxin cardiotoxicity. However, it was observed that the haemolytically more active EqT III is less toxic than EqT I, the most toxic and least haemolytic EqT. In mice, EqT II is more than 30 times more toxic than OlyA/PlyB when applied intravenously. These observations imply that haemolysis with hyperkalaemia is not the sole cause of the lethal activity of both toxins. Additional mechanisms responsible for lethal action of the two toxins are direct effects on heart, coronary vasoconstriction and related myocardial hypoxia. In this review, we appraise the pathophysiological mechanisms related to the chemical structure of OlyA/PlyB and EqTs, as well as their toxicity.

Jezik:Angleški jezik
Ključne besede:ostreolysin A/pleurotolysin B, equinatoxins, pore-forming proteins, biological effects, pore forming cytotoxic proteins, relative biological effectiveness
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
MF - Medicinska fakulteta
Leto izida:2017
Št. strani:10 str.
Številčenje:Vol. 9, iss. 4, art. 128
UDK:577
ISSN pri članku:2072-6651
DOI:10.3390/toxins9040128 Povezava se odpre v novem oknu
COBISS.SI-ID:4296570 Povezava se odpre v novem oknu
Število ogledov:39
Število prenosov:12
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Toxins
Skrajšan naslov:Toxins
Založnik:MDPI
ISSN:2072-6651
COBISS.SI-ID:517594649 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Proteus
Številka projekta:BI-FR-PROTEUS/17-18-001, 37446QC

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P4-0053
Naslov:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P3-0019
Naslov:Aplikativna in bazična fiziologija in patofiziologija v medicini

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:05.04.2017

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