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Trans-membrane area asymmetry controls the shape of cellular organelles
ID
Beznoussenko, Galina V.
(
Avtor
),
ID
Pilyugin, Sergei S.
(
Avtor
),
ID
Geerts, Willie J. C.
(
Avtor
),
ID
Kozlov, Michael M.
(
Avtor
),
ID
Burger, Koert N. J.
(
Avtor
),
ID
Luini, Alberto
(
Avtor
),
ID
Derganc, Jure
(
Avtor
),
ID
Mironov, Alexander A.
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(3,62 MB)
MD5: 3E62C951B91C00C5B187A117A2643635
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1422-0067/16/3/5299
Galerija slik
Izvleček
Membrane organelles often have complicated shapes and differ in their volume, surface area and membrane curvature. The ratio between the surface area of the cytosolic and luminal leaflets (trans-membrane area asymmetry (TAA)) determines the membrane curvature within different sites of the organelle. Thus, the shape of the organelle could be critically dependent on TAA. Here, using mathematical modeling and stereological measurements of TAA during fast transformation of organelle shapes, we present evidence that suggests that when organelle volume and surface area are constant, TAA can regulate transformation of the shape of the Golgi apparatus, endosomal multivesicular bodies, and microvilli of brush borders of kidney epithelial cells. Extraction of membrane curvature by small spheres, such as COPI-dependent vesicles within the Golgi (extraction of positive curvature), or by intraluminal vesicles within endosomes (extraction of negative curvature) controls the shape of these organelles. For instance, Golgi tubulation is critically dependent on the fusion of COPI vesicles with Golgi cisternae, and vice versa, for the extraction of membrane curvature into 50-60 nm vesicles, to induce transformation of Golgi tubules into cisternae. Also, formation of intraluminal ultra-small vesicles after fusion of endosomes allows equilibration of their TAA, volume and surface area. Finally, when microvilli of the brush border are broken into vesicles and microvilli fragments, TAA of these membranes remains the same as TAA of the microvilli. Thus, TAA has a significant role in transformation of organelle shape when other factors remain constant.
Jezik:
Angleški jezik
Ključne besede:
lipid membrane
,
asymmetry
,
Golgi apparatus
,
intra-Golgi transport
,
trans-membrane area asymmetry
,
organelle shape
,
kiss-and-run model
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2015
Št. strani:
Str. 5299-5333
Številčenje:
Vol. 16, iss. 3
PID:
20.500.12556/RUL-130503
UDK:
577
ISSN pri članku:
1422-0067
DOI:
10.3390/ijms16035299
COBISS.SI-ID:
32179417
Datum objave v RUL:
15.09.2021
Število ogledov:
1087
Število prenosov:
145
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Objavi na:
Gradivo je del revije
Naslov:
International journal of molecular sciences
Skrajšan naslov:
Int. j. mol. sci.
Založnik:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
09.03.2015
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
lipidna membrana
,
asimetrija
,
Golgijev aparat
Projekti
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Consorzio Mario Negri Sud
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
FIRC (Italy)
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