Determination of solubility parameters of ibuprofen and ibuprofen lysinate

Kitak, Teja (avtor), Dumičić, Aleksandra (avtor), Planinšek, Odon (avtor), Šibanc, Rok (avtor), Srčič, Stanko (avtor)

In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were determined in two different ways: solely by using calculation methods, and by experimental approaches. Six different calculation methods were applied in order to calculate the solubility parameters of the drug ibuprofen and several excipients. However, we were not able to do so in the case of ibuprofen lysinate, as calculation models for salts are still not defined. Therefore, the extended Hansenʼs approach and inverse gas chromatography (IGC) were used for evaluating of solubility parameters for ibuprofen lysinate. The obtained values of the total solubility parameter did not differ much between the two methods: by the extended Hansenʼs approach it was δt=31.15 MPa$^{0.5}$ and with IGC it was δ$_t$ = 35.17 MPa$^{0.5}$. However, the values of partial solubility parameters, i.e., δ$_d$, δ$_p$ and δ$_h$, did differ from each other, what might be due to the complex behaviour of a salt in the presence of various solvents.

• Jezik: Angleški jezik
• Ključne besede: Hansenʼs solubility parameters, extended Hansenʼs approach, inverse gas chromatography, ibuprofen, ibuprofen lysinate
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2015
• Št. strani: Str. 21549-21568
• Številčenje: Vol. 20, iss. 12
• PID: 20.500.12556/RUL-130389
• UDK: 615.011
• ISSN pri članku: 1420-3049
• DOI: 10.3390/molecules201219777
• COBISS.SI-ID: 3983985
• Datum objave v RUL: 14.09.2021

Gradivo je del revije

• Naslov: Molecules
• Skrajšan naslov: Molecules
• Založnik: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 03.12.2015

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: R & D Labs of Zenitva k.s.

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: Faculty of Pharmacy, University of Ljubljana