Determination of solubility parameters of ibuprofen and ibuprofen lysinate

Kitak, Teja (author), Dumičić, Aleksandra (author), Planinšek, Odon (author), Šibanc, Rok (author), Srčič, Stanko (author)

In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were determined in two different ways: solely by using calculation methods, and by experimental approaches. Six different calculation methods were applied in order to calculate the solubility parameters of the drug ibuprofen and several excipients. However, we were not able to do so in the case of ibuprofen lysinate, as calculation models for salts are still not defined. Therefore, the extended Hansenʼs approach and inverse gas chromatography (IGC) were used for evaluating of solubility parameters for ibuprofen lysinate. The obtained values of the total solubility parameter did not differ much between the two methods: by the extended Hansenʼs approach it was δt=31.15 MPa$^{0.5}$ and with IGC it was δ$_t$ = 35.17 MPa$^{0.5}$. However, the values of partial solubility parameters, i.e., δ$_d$, δ$_p$ and δ$_h$, did differ from each other, what might be due to the complex behaviour of a salt in the presence of various solvents.

• Language: English
• Keywords: Hansenʼs solubility parameters, extended Hansenʼs approach, inverse gas chromatography, ibuprofen, ibuprofen lysinate
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2015
• Number of pages: Str. 21549-21568
• Numbering: Vol. 20, iss. 12
• PID: 20.500.12556/RUL-130389
• UDC: 615.011
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules201219777
• COBISS.SI-ID: 3983985
• Publication date in RUL: 14.09.2021

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 03.12.2015

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: R & D Labs of Zenitva k.s.

• Funder: Other - Other funder or multiple funders
• Funding programme: Faculty of Pharmacy, University of Ljubljana