20.500.12556/RUL-130389 Determination of solubility parameters of ibuprofen and ibuprofen lysinate In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were determined in two different ways: solely by using calculation methods, and by experimental approaches. Six different calculation methods were applied in order to calculate the solubility parameters of the drug ibuprofen and several excipients. However, we were not able to do so in the case of ibuprofen lysinate, as calculation models for salts are still not defined. Therefore, the extended Hansenʼs approach and inverse gas chromatography (IGC) were used for evaluating of solubility parameters for ibuprofen lysinate. The obtained values of the total solubility parameter did not differ much between the two methods: by the extended Hansenʼs approach it was δt=31.15 MPa$^{0.5}$ and with IGC it was δ$_t$ = 35.17 MPa$^{0.5}$. However, the values of partial solubility parameters, i.e., δ$_d$, δ$_p$ and δ$_h$, did differ from each other, what might be due to the complex behaviour of a salt in the presence of various solvents. Hansenʼs solubility parameters extended Hansenʼs approach inverse gas chromatography ibuprofen ibuprofen lysinate true false true Angleški jezik Ni določen Članek v reviji 2021-09-14 11:47:40 2021-09-14 11:47:42 2022-09-09 04:16:13 0000-00-00 00:00:00 2015 0 0 Str. 21549-21568 iss. 12 Vol. 20 2015 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.011 1420-3049 10.3390/molecules201219777 3983985 RAZ_Kitak_Teja_2015.pdf RAZ_Kitak_Teja_2015.pdf 1 D454E6A7140EFC7CBDC0D526494683A1 87bf788d45ca9ff5ee2b68605681cad22ba01c02f943859ffcecdc7ff165ac13 5b797e22-1548-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=147494 http://www.mdpi.com/1420-3049/20/12/19777 1 8d1ad360-1540-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=147492 Fakulteta za farmacijo 0 0 0