Astrocytic vesicle mobility in health and disease

Potokar, Maja (avtor), Vardjan, Nina (avtor), Stenovec, Matjaž (avtor), Trkov, Saša (avtor), Jorgačevski, Jernej (avtor), Kreft, Marko (avtor), Zorec, Robert (avtor)

Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5'-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions.

• Jezik: Angleški jezik
• Ključne besede: astrocyte, glia, vesicle, trafficking, gliotransmitter, antigen presentation, neuroinflammation, amyotrophic lateral sclerosis, multiple sclerosis
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta ; BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2013
• Št. strani: Str. 11238-11258
• Številčenje: Vol. 14, iss. 6
• PID: 20.500.12556/RUL-129252
• UDK: 616-092
• ISSN pri članku: 1661-6596
• DOI: 10.3390/ijms140611238
• COBISS.SI-ID: 30620377
• Datum objave v RUL: 31.08.2021

POTOKAR, Maja, VARDJAN, Nina, STENOVEC, Matjaž, TRKOV, Saša, JORGAČEVSKI, Jernej, KREFT, Marko in ZOREC, Robert, 2013, Astrocytic vesicle mobility in health and disease. International journal of molecular sciences [na spletu]. 2013. Vol. 14, no. 6, p. 11238–11258. [Dostopano 26 april 2025]. DOI 10.3390/ijms140611238. Pridobljeno s: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=slv&id=129252

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1661-6596
• COBISS.SI-ID: 36217605

Licence

• Licenca: CC BY 3.0, Creative Commons Priznanje avtorstva 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by/3.0/deed.sl
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• Začetek licenciranja: 01.06.2013

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: glija, astrociti, multipla skleroza