Immunosenescence describes changes in the entire immune system that occur during aging. In innate immunity immunosenescence reduces macrophage activity, reduces number of monocyte and dendritic cells, and deteriorates presentation of antigens. In adaptive immunity immunosenescence causes reduction of receptors in T and B cells and an accumulation of non-functional T cells. These changes with SARS-CoV-2 infection result in a more severe course of the disease. The presence of higher amounts of cytokines with an immunosenescent immune response results in poorer clearance of SARS-CoV-2. Immunosenescent innate immune response with excessive production of inflammatory cytokines causes development of a cytokine storm and more severe complications in COVID-19. It si necessary to know effective ways of passive treatments. There are different passive treatment options available from mechanical respiration, inhibition of cytokines to passive vaccination. During choosing of a treatment for a patient, it is necessary to examine the entire medical condition of the patient with all the associated diagnoses, as the wrong form of therapy can worsen the medical condition.
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