izpis_h1_title_alt

The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer
ID Lukanović, David (Avtor), ID Herzog, Maruša (Avtor), ID Kobal, Borut (Avtor), ID Černe, Katarina (Avtor)

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Izvleček
Ovarian cancer has the highest mortality rate among all gynecologic cancers, with most patients presenting with advanced stage tumors. About a third of patients do not respond to primary platinum-based chemotherapy treatment, and over time up to 80 % of others develop chemoresistance, rendering recurrent disease incurable. Moreover, according to latest EMSO-ESGO (European Society for Medical Oncology - European Society for Gynecological Oncology) consensus conference manuscript on ovarian cancer, there are currently no validated molecular predictive biomarkers for platinum resistance. Recent studies suggest that the copper efflux transporters ATP7A and ATP7B play an important role in platinum resistance. In addition, by exploring their role in mediating resistance, new pathways of platinum resistance emerge, such as lysosomal storage disorders, which might be explored in the future as a new target to circumvent platinum resistance. This review outlines a challenging clinical hurdle in ovarian cancer therapy due to platinum resistance, links between the essential trace element copper and cytotoxic platinum-based medicines, and enigmatic mechanisms of ATP7A and ATP7B mediating platinum resistance. It then presents clinical studies showing a significant association of ATP7A and ATP7B with response to cisplatin/carboplatin and prognosis. Based on the results of in vitro assays, disease-relevant animal models, and clinical studies to date, it may be concluded that APT7A and ATP7B deserve further development as predictive markers of platinum resistance in ovarian cancer. Both transporters could play a particularly important role in early estimation of therapy response to identify platinum-resistant tumors and to adjust the treatment of ovarian cancer patients accordingly.

Jezik:Angleški jezik
Ključne besede:gyneacology, ovarian cancer, chemoresistance, predictive marker, ATP7A, ATP7B
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2020
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:12 str.
Številčenje:Vol. 129, art. 110401
UDK:618.1
ISSN pri članku:1950-6007
DOI:10.1016/j.biopha.2020.110401 Povezava se odpre v novem oknu
COBISS.SI-ID:21068547 Povezava se odpre v novem oknu
Datum objave v RUL:29.07.2021
Število ogledov:251
Število prenosov:75
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Biomedicine & pharmacotherapy
Založnik:Elsevier
ISSN:1950-6007
COBISS.SI-ID:23136261 Povezava se odpre v novem oknu

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:01.09.2020

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:ginekologija, rak jajčnika, kemoresistenca, ATP7A, ATP7B

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P3-0067
Naslov:Farmakologija in farmakogenomika

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Ljubljana University Medical Center
Številka projekta:20180033
Naslov:Transport proteins as biomarkers for selecting the optimal time for cytoreductive surgery in cancer

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