izpis_h1_title_alt

Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson's disease
ID Redenšek Trampuž, Sara (Avtor), ID Flisar, Dušan (Avtor), ID Kojović, Maja (Avtor), ID Gregorič Kramberger, Milica (Avtor), ID Georgiev, Dejan (Avtor), ID Pirtošek, Zvezdan (Avtor), ID Trošt, Maja (Avtor), ID Dolžan, Vita (Avtor)

.pdfPDF - Predstavitvena datoteka, prenos (673,75 KB)
MD5: 339D0B08E4A95F89803DAD371752E120
URLURL - Izvorni URL, za dostop obiščite https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1439-y Povezava se odpre v novem oknu

Izvleček
Background: Inflammation and oxidative stress are recognized as important contributors to Parkinson's disease pathogenesis. As such, genetic variability in these pathways could have a role in susceptibility for the disease as well as in the treatment outcome. Dopaminergic treatment is effective in management of motor symptoms, but poses a risk for motor and non-motor adverse events. Our aim was to evaluate the impact of selected single-nucleotide polymorphisms in genes involved in inflammation and oxidative stress on Parkinson's disease susceptibility and the occurrence of adverse events of dopaminergic treatment. Methods: In total, 224 patients were enrolled, and their demographic and clinical data on the disease course were collected. Furthermore, a control group of 146 healthy Slovenian blood donors were included for Parkinson's disease' risk evaluation. Peripheral blood was obtained for DNA isolation. Genotyping was performed for NLRP3 rs35829419, CARD8 rs2043211, IL1β rs16944, IL1β rs1143623, IL6 rs1800795, CAT rs1001179, CAT rs10836235, SOD2 rs4880, NOS1 rs2293054, NOS1 rs2682826, TNF-α rs1800629, and GPX1 rs1050450. Logistic regression was used for analysis of possible associations. Results: We observed a nominally significant association of the IL1β rs1143623 C allele with the risk for Parkinson's disease (OR=0.59; 95%CI=0.38-0.92, p=0.021). CAT rs1001179 A allele was significantly associated with peripheral edema (OR=0.32; 95%CI=0.15-0.68; p=0.003). Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR=1.75; 95%CI=1.00-3.06, p=0.048), SOD2 rs4880 T allele and nausea/vomiting (OR=0.49, 95%CI=0.25-0.94; p=0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR=0.57, 95%CI=0.32-1.00, p=0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR=2.59; 95%CI=1.09-6.19; p=0.032). We did not find any associations between selected polymorphisms and motor adverse events. Conclusions: Apart from some nominally significant associations, one significant association between CAT genetic variability and peripheral edema was observed as well. Therefore, the results of our study suggest some links between genetic variability in inflammation- and oxidative stress-related pathways and non-motor adverse events of dopaminergic treatment. However, the investigated polymorphisms do not play a major role in the occurrence of the disease and the adverse events of dopaminergic treatment.

Jezik:Angleški jezik
Ključne besede:Parkinson's disease, susceptibility, polymorphism, inflammation, oxidative stress, adverse events
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2019
Št. strani:12 str.
Številčenje:Vol. 16, art. 50
PID:20.500.12556/RUL-128757 Povezava se odpre v novem oknu
UDK:616.8
ISSN pri članku:1742-2094
DOI:10.1186/s12974-019-1439-y Povezava se odpre v novem oknu
COBISS.SI-ID:34211545 Povezava se odpre v novem oknu
Datum objave v RUL:27.07.2021
Število ogledov:792
Število prenosov:145
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
:
Kopiraj citat
Objavi na:Bookmark and Share

Gradivo je del revije

Naslov:Journal of neuroinflammation
Skrajšan naslov:J. neuroinflamm.
Založnik:Springer Nature
ISSN:1742-2094
COBISS.SI-ID:513966617 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:27.02.2019

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:Parkinsonova bolezen, dovzetnost, polimorfizem, vnetje, oksidativni stres, škodljivi dogodki

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P1-0170
Naslov:Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Program financ.:Grant for young researchers

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Nazaj