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Relationship between circulating vascular endothelial growth factor and its soluble receptor in patients with hemorrhagic fever with renal syndrome
ID
Pal, Emil
(
Avtor
),
ID
Korva, Miša
(
Avtor
),
ID
Resman Rus, Katarina
(
Avtor
),
ID
Kejžar, Nataša
(
Avtor
),
ID
Bogovič, Petra
(
Avtor
),
ID
Strle, Franc
(
Avtor
),
ID
Avšič-Županc, Tatjana
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(968,54 KB)
MD5: DF4B9012DEA8F1D81C4D6F63665409DA
URL - Izvorni URL, za dostop obiščite
https://www.tandfonline.com/doi/full/10.1038/s41426-018-0090-5
Galerija slik
Izvleček
Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2) in HFRS patients infected with Dobrava (DOBV) or Puumala virus (PUUV). VEGF and sVEGFR-2 levels were measured in daily plasma and urine samples of 73 patients with HFRS (58 with PUUV, 15 with DOBV) and evaluated in relation to clinical and laboratory variables. In comparison with the healthy controls, initial samples (obtained in the first week of illness) from patients with HFRS had higher plasma and urine VEGF levels, whereas sVEGFR-2 levels were lower in plasma but higher in urine. VEGF levels did not differ in relation to hantavirus species, viral load, or the severity of HFRS. The comparison of VEGF dynamics in plasma and urine showed the pronounced secretion of VEGF in urine. Significant correlations were found between daily VEGF/sVEGFR-2 levels and platelet counts, as well as with diuresis: the correlations were positive for plasma VEGF/sVEGFR-2 levels and negative for urine levels. In addition, patients with hemorrhagic manifestations had very high plasma and urine VEGF, together with high urine sVEGFR-2. Measuring the local secretion of sVEGFR-2 in urine might be a useful biomarker for identifying HFRS patients who will progress to severe disease.
Jezik:
Angleški jezik
Ključne besede:
hemorrhagic fever
,
vascular endothelial growth factor
,
soluble receptor
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2018
Št. strani:
9 str.
Številčenje:
Vol. 7, art. 89
PID:
20.500.12556/RUL-128736
UDK:
616.9
ISSN pri članku:
2222-1751
DOI:
10.1038/s41426-018-0090-5
COBISS.SI-ID:
33775577
Opomba:
V datoteki založnikove različice članka (PDF) je dodana uvodna stran, na kateri je kot založnik naveden Taylor and Francis. V samem članku je kot založnik naveden Nature (v glavi prve strani) oz. Springer Nature (na predzadnji strani pod naslovom Publisher's note). Pristajalna stran članka (URL) sodi med spletne strani založnika Taylor and Francis. (28. 7. 2021)
Datum objave v RUL:
26.07.2021
Število ogledov:
1202
Število prenosov:
181
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Emerging microbes & infections
Skrajšan naslov:
Emerg. microbes & infect.
Založnik:
Springer Nature
ISSN:
2222-1751
COBISS.SI-ID:
523072793
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
16.05.2018
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
hemoragična mrzlica
,
vaskularni endotelijski rastni faktor
,
topni receptor
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0083
Naslov:
Odnosi parazitskega obstajanja
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
U.S. Civilian Research and Development Foundation
Številka projekta:
SIB1-2964-LJ-09
Financer:
EC - European Commission
Program financ.:
H2020
Številka projekta:
653316
Naslov:
European Virus Archive goes global
Akronim:
EVAg
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