20.500.12556/RUL-128736 Relationship between circulating vascular endothelial growth factor and its soluble receptor in patients with hemorrhagic fever with renal syndrome Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2) in HFRS patients infected with Dobrava (DOBV) or Puumala virus (PUUV). VEGF and sVEGFR-2 levels were measured in daily plasma and urine samples of 73 patients with HFRS (58 with PUUV, 15 with DOBV) and evaluated in relation to clinical and laboratory variables. In comparison with the healthy controls, initial samples (obtained in the first week of illness) from patients with HFRS had higher plasma and urine VEGF levels, whereas sVEGFR-2 levels were lower in plasma but higher in urine. VEGF levels did not differ in relation to hantavirus species, viral load, or the severity of HFRS. The comparison of VEGF dynamics in plasma and urine showed the pronounced secretion of VEGF in urine. Significant correlations were found between daily VEGF/sVEGFR-2 levels and platelet counts, as well as with diuresis: the correlations were positive for plasma VEGF/sVEGFR-2 levels and negative for urine levels. In addition, patients with hemorrhagic manifestations had very high plasma and urine VEGF, together with high urine sVEGFR-2. Measuring the local secretion of sVEGFR-2 in urine might be a useful biomarker for identifying HFRS patients who will progress to severe disease. hemorrhagic fever vascular endothelial growth factor soluble receptor hemoragična mrzlica vaskularni endotelijski rastni faktor topni receptor true false true Angleški jezik Slovenski jezik Članek v reviji 2021-07-26 13:04:41 2021-07-26 13:04:46 2022-09-07 04:16:54 0000-00-00 00:00:00 2018 0 0 V datoteki založnikove različice članka (PDF) je dodana uvodna stran, na kateri je kot založnik naveden Taylor and Francis. V samem članku je kot založnik naveden Nature (v glavi prve strani) oz. Springer Nature (na predzadnji strani pod naslovom Publisher's note). Pristajalna stran članka (URL) sodi med spletne strani založnika Taylor and Francis. (28. 7. 2021) 9 str. Vol. 7, art. 89 May 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2222-1751 10.1038/s41426-018-0090-5 33775577 RAZ_Pal_Emil_2018.pdf RAZ_Pal_Emil_2018.pdf 1 DF4B9012DEA8F1D81C4D6F63665409DA 51a195df1b50a8c58c79c45e91f19c1a81e43b7245db93a73f3b197f849efbbd c3f05d37-ef8d-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145642 https://www.tandfonline.com/doi/full/10.1038/s41426-018-0090-5 0 214840dc-ee01-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145571 Medicinska fakulteta 0 0 0