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The DNA damage inducible SOS response is a key player in the generation of bacterial persister cells and population wide tolerance
ID
Podlesek, Zdravko
(
Avtor
),
ID
Žgur-Bertok, Darja
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(289,53 KB)
MD5: 39AA60E01FE1EB96B9E6F0C17EBD47E3
URL - Izvorni URL, za dostop obiščite
https://www.frontiersin.org/articles/10.3389/fmicb.2020.01785/full
Galerija slik
Izvleček
Population-wide tolerance and persisters enable susceptible bacterial cells to endure hostile environments, including antimicrobial exposure. The SOS response can play a significant role in the generation of persister cells, population-wide tolerance, and shielding. The SOS pathway is an inducible DNA damage repair system that is also pivotal for bacterial adaptation, pathogenesis, and diversification. In addition to the two key SOS regulators, LexA and RecA, some other stressors and stress responses can control SOS factors. Bacteria are exposed to DNA-damaging agents and other environmental and intracellular factors, including cigarette smoke, that trigger the SOS response at a number of sites within the host. The Escherichia coli TisB/IstR module is as yet the only known SOS-regulated toxin–antitoxin module involved in persister formation. Nevertheless, the SOS response plays a key role in the formation of biofilms that are highly recalcitrant to antimicrobials and can be abundant in persisters. Furthermore, the dynamic biofilm environment generates DNA-damaging factors that trigger the SOS response within the biofilm, fueling bacterial adaptation and diversification. This review highlights the SOS response in relation to antimicrobial recalcitrance to antimicrobials in four clinically significant species, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Mycobacterium tuberculosis.
Jezik:
Angleški jezik
Ključne besede:
SOS response
,
persisters
,
tolerance
,
biofilms
,
bacterial pathogens/opportunists
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
8 str.
Številčenje:
Vol. 11, art. 1785
PID:
20.500.12556/RUL-128312
UDK:
577.2
ISSN pri članku:
1664-302X
DOI:
10.3389/fmicb.2020.01785
COBISS.SI-ID:
26608643
Datum objave v RUL:
08.07.2021
Število ogledov:
739
Število prenosov:
193
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Frontiers in microbiology
Skrajšan naslov:
Front. microbiol.
Založnik:
Frontiers Research Foundation
ISSN:
1664-302X
COBISS.SI-ID:
4146296
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
04.08.2020
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0198
Naslov:
Molekularno-biološke raziskave mikroorganizmov
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