Nephrotic syndrome is an ensemble of symptoms, that result in kidney failure. Congenital nephrotic syndrome is an autosomal recessive ilness, for which the nephrotic syndrome is present in the first three months of life. Children, that are treated of chronical kidney disease, are usually and often hospitalised, that is why a delay in motor skills development can occur. The development of motor skills is very important in preschool phase, since in this phase children intensively develop basic motor skills, that are important for full development. We have made a case study with which we have analysed the functions of a four year-old girl, that was diagnosed with congenital nephrotic syndroem the second day after her birth. Around the girl’s eight month, both her kidneys were removed. The period of dialysis that was done by the parents in their home followed. By the girl’s second year, her kidney was transplanted. With the ABC motor skill 2 test instrumentarium we checked the girl’s motor skills. Based on the results we designed a help program that enabled a systematic motor skills development. An eight week program was conducted by the girl’s parents at their home, four times per week for half an hour. After the finished program, we re-tested her motor skills with the ABC motor skill 2 test instrumentarium. During the first measurement the results showed that the girl doesn’t have any motor skill problems. We noticed a slight bad fine motor skills and some problems with static balance conservation. With the help of an eight week program the girl has improved the raw achievements, while the standard achievements and centiles during the start and end measurement were the same. It is important to point out the girl has improved the quality of her motor skills. She improved the perseverance and motivation during the execution of the program exercises.