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Genomic insights into the emergence and spread of methicillin-resistant Staphylococcus pseudintermedius in veterinary clinics
ID Papić, Bojan (Avtor), ID Golob, Majda (Avtor), ID Zdovc, Irena (Avtor), ID Kušar, Darja (Avtor), ID Avberšek, Jana (Avtor)

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Izvleček
Staphylococcus pseudintermedius is a common cause of skin and soft tissue infections in dogs but can also cause infections in cats and humans. The frequency of methicillin-resistant S. pseudintermedius (MRSP) strains is increasing worldwide. Here, we obtained 43 MRSP isolates from dogs (n = 41), one cat (n = 1) and the small animal clinic environment (n = 1) in Slovenia from the period 2008–2018, which underwent whole-genome sequencing (WGS) and antimicrobial susceptibility testing. Five sequence types (STs) were identified, with ST71 (32/43) and ST551 (8/43) being the predominant. In Slovenia, ST551 was first detected in 2016, whereas a decrease in the frequency of ST71 was observed after 2015. All isolates were multidrug-resistant and most antimicrobial-resistant phenotypes could be linked to acquisition of the corresponding resistance genes or gene mutations. Core-genome multilocus sequence typing (cgMLST) revealed several potential MRSP transmission routes: (i) between two veterinary clinics by a single MRSP-positive dog, (ii) between the environment of a veterinary clinic and a dog, and (iii) between a canine and a feline patient through the contaminated environment of a veterinary clinic. Of the six dogs that were additionally sampled from 14 days to five months after the initial sampling, each harbored the same MRSP strain, suggesting a limited within-host diversity of MRSP in symptomatic dogs. The present results highlight the importance of MRSP-positive dogs in the spread of veterinary care-associated MRSP infections and call for the implementation of strict control measures to reduce MRSP contamination in veterinary clinic environments originating from animal-contact surfaces.

Jezik:Angleški jezik
Ključne besede:antimicrobial susceptibility testing, epidemiology, methicillin-resistant Staphylococcus pseudintermedius (MRSP), small animal clinic, whole-genome sequencing (WGS)
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Leto izida:2021
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:7 str.
Številčenje:Vol. 258, art. 109119
PID:20.500.12556/RUL-127443 Povezava se odpre v novem oknu
UDK:636.09:579
ISSN pri članku:1873-2542
DOI:10.1016/j.vetmic.2021.109119 Povezava se odpre v novem oknu
COBISS.SI-ID:64516867 Povezava se odpre v novem oknu
Datum objave v RUL:07.06.2021
Število ogledov:475
Število prenosov:152
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Veterinary microbiology
Skrajšan naslov:Vet. microbiol.
Založnik:Elsevier
ISSN:1873-2542
COBISS.SI-ID:23130885 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J4-8224
Naslov:Ugotavljanje in karakterizacija povzročiteljev kužnih bolezni z metodo naslednje generacije sekvenciranja

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P4-0092
Naslov:Zdravje živali, okolje in varna hrana

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