Simultaneous introduction of two different palladium (pre)catalysts, one tuned to promote oxidative addition to (hetero)aryl bromide and another to activate terminal alkyne substrate, leads to productive Pd−Pd transmetalation, subsequent reductive elimination, and formation of disubstituted alkyne. This conceptually novel rational design of copper-free Sonogashira reaction enabled facile identification of the reaction conditions, suitable for the synthesis of alkyl, aryl, and heteroaryl substituted alkynes at room temperature with as low as 0.125 mol % total Pd loading.
| Jezik: | Angleški jezik |
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| Ključne besede: | catalysis, palladium, Sonogashira reaction, alkyne, hydrocarbons, copper, ligands, addition reactions |
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| Vrsta gradiva: | Članek v reviji (dk_c) |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FKKT - Fakulteta za kemijo in kemijsko tehnologijo
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| Leto izida: | 2020 |
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| Status objave pri reviji: | Objavljeno |
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| Verzija članka: | Založnikova različica članka |
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| Št. strani: | Str. 4938-4943 |
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| Številčenje: | Vol. 22, iss. 13 |
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| UDK: | 547:544.47:546.98 |
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| ISSN pri članku: | 1523-7060 |
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| DOI: | 10.1021/acs.orglett.0c01227  |
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| COBISS.SI-ID: | 14359811 |
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| Datum objave v RUL: | 12.03.2021 |
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| Število ogledov: | 314 |
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| Število prenosov: | 140 |
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| Metapodatki: |     |
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