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A mathematical model for pH-responsive ionically crosslinked TEMPO nanocellulose hydrogel design in drug delivery systems
Kopač, Tilen (Author), Krajnc, Matjaž (Author), Ručigaj, Aleš (Author)

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Abstract
Ionically crosslinked hydrogels based on TEMPO nanocelullose and alginate were prepared to develop a generalized pH value, temperature and biopolymer concentration dependent mathematical model. The distinctive attention was in the demonstration of hydrogen bonds effects in the mathematical model, prevailing especially in the field of low crosslink densities of TEMPO nanocellulose hydrogel in acid medium. Accordingly, alginate hydrogelswere subjected to the research as comparable samples with less significant hydrogel bonds effect. The equation was built upon the determination of the average mesh size in a TEMPO nanocellulose and alginate hydrogel network and studying its changes in different pH release environments. Based on rheological measurements of TEMPO nanocellulose and alginate from the basic and acidic release environment, the mechanism of swelling and shrinkage was thoroughly discussed as well as the influence of substituent groups, ionic interactions and hydrogen bonds in different pH medium were evaluated. Due to the protonation of carboxylic groups, TEMPO nanocellulose and alginate hydrogels shrink in an acid environment. The presented approach will accelerate, improve and reduce the cost of research in the field of controlled release technology with target drug delivery.

Language:English
Keywords:TEMPO nanocellulose, pH sensitive hydrogel, controlled drug delivery system
Work type:Article (dk_c)
Tipology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2021
Number of pages:Str. 695-707
Numbering:Vol. 168
UDC:661.728:620.3
ISSN on article:0141-8130
DOI:10.1016/j.ijbiomac.2020.11.126 This link opens in a new window
COBISS.SI-ID:40059651 This link opens in a new window
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Downloads:198
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Record is a part of a journal

Title:International journal of biological macromolecules
Shortened title:Int. j. biol. macromol.
Publisher:Elsevier
ISSN:0141-8130
COBISS.SI-ID:25637888 This link opens in a new window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P2-0191
Name:Kemijsko inženirstvo

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:02.12.2020

Secondary language

Language:Slovenian
Keywords:TEMPO nanoceluloza, pH odzivni hidrogel, dostavni sistem učinkovin, kontrolirano sproščanje

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