20.500.12556/RUL-122254 A mathematical model for pH-responsive ionically crosslinked TEMPO nanocellulose hydrogel design in drug delivery systems Ionically crosslinked hydrogels based on TEMPO nanocelullose and alginate were prepared to develop a generalized pH value, temperature and biopolymer concentration dependent mathematical model. The distinctive attention was in the demonstration of hydrogen bonds effects in the mathematical model, prevailing especially in the field of low crosslink densities of TEMPO nanocellulose hydrogel in acid medium. Accordingly, alginate hydrogelswere subjected to the research as comparable samples with less significant hydrogel bonds effect. The equation was built upon the determination of the average mesh size in a TEMPO nanocellulose and alginate hydrogel network and studying its changes in different pH release environments. Based on rheological measurements of TEMPO nanocellulose and alginate from the basic and acidic release environment, the mechanism of swelling and shrinkage was thoroughly discussed as well as the influence of substituent groups, ionic interactions and hydrogen bonds in different pH medium were evaluated. Due to the protonation of carboxylic groups, TEMPO nanocellulose and alginate hydrogels shrink in an acid environment. The presented approach will accelerate, improve and reduce the cost of research in the field of controlled release technology with target drug delivery. TEMPO nanocellulose pH sensitive hydrogel controlled drug delivery system TEMPO nanoceluloza pH odzivni hidrogel dostavni sistem učinkovin kontrolirano sproščanje true false true Angleški jezik Slovenski jezik Članek v reviji 2020-12-02 07:53:58 2020-12-02 08:00:00 2022-09-02 04:02:49 0000-00-00 00:00:00 2021 0 0 Str. 695-707 Vol. 168 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 661.728:620.3 0141-8130 10.1016/j.ijbiomac.2020.11.126 40059651 25637888 RAZ_Kopac_Tilen_2021.pdf RAZ_Kopac_Tilen_2021.pdf 1 3E31597BED57476760D0CF022126ED44 66dcc1689d9e263baf06ddf49c0747cb4be954ef4dae398a55f69eb5061892aa a820b604-a1bb-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=140675 https://www.sciencedirect.com/science/article/pii/S0141813020350522 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=137438 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0