Aripiprazole reduces liver cell division : research data underlying the article

Pirc Marolt, Tinkara (avtor), Kramar, Barbara (avtor), Bulc Rozman, Klara (avtor), Šuput, Dušan (avtor), Milisav, Irina (avtor)

Effects of aripiprazole on dopamine regulation are being tested as a treatment for patients with a dual diagnosis of schizophrenia and addictions, often cocaine dependence. Aripiprazole has one of the fewest side-effects among the second-generation antipsychotics. Nevertheless, severe aripiprazole hepatotoxicity was reported in persons with a history of cocaine and alcohol abuse. Here we report that therapeutically relevant aripiprazole concentrations, equal to laboratory alert levels in patients’ serum, reduce the rate of hepatocytes’ division. This could be an underlying mechanism of severe liver injury development in the patients with a history of alcohol and cocaine abuse, the two hepatotoxic agents that require increased ability of liver self-regeneration. Monitoring liver functions is, therefore, important in the cases when aripiprazole is co-prescribed or used with drugs with potential hepatotoxic effects.

• Jezik: Angleški jezik
• Ključne besede: Aripiprazole, Olanzapine, chemical and drug induced liver injury, antipsychotics, second-generation antipsychotics
• Organizacija: MF - Medicinska fakulteta
• Kraj izida: Ljubljana
• Leto izida: 2020
• PID: 20.500.12556/RUL-121367
• Datum objave v RUL: 06.10.2020

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0019
• Naslov: Aplikativna in bazična fiziologija in patofiziologija v medicini

• Financer: EC - European Commission
• Program financ.: H2020
• Številka projekta: 721236
• Naslov: Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia
• Akronim: TREATMENT