izpis_h1_title_alt

Načrtovanje in sinteza 2-amino-2-oksoetil-N-(arilsulfonil)karbamatov kot inhibitorjev Murc in MurD : diplomska naloga
Cirkvenčič, Nina (Avtor), Obreza, Aleš (Mentor) Več o mentorju... Povezava se odpre v novem oknu, Frlan, Rok (Komentor)

.pdfPDF - Predstavitvena datoteka, prenos (1,11 MB)
MD5: 5AE6B65CB81CC5BC62B31322C91BBAB6

Izvleček
After coronary artery bypass grafting, which are the most common types of cardiac surgery, develops acute renal injury requiring replacement therapy in 1–5 %. They are associated with high rates of morbidity and mortality. For this relevant clinical problem, it is recommended to monitor renal function after surgery. Standard parameters for investigating renal function in clinical routine are serum creatinine, measured creatinine clearance and in present time a prediction equation to estimate glomerular filtration rate (GFR) from serum creatinine by the MDRD study equation, but they all are based on measurement of serum creatinine, which is influenced by a lot of factors such as formation and excretion of creatinine and method of determination. In our study we included also a new marker of renal function serum cystatin C and predicted estimate GFR from serum cystatin C. We performed a prospective and partly randomized trial in 50 patients, half of the patients were operated on coronary arteries with cardiopulmonary bypass and the other half of patients were operated without cardiopulmonary bypass. Renal function was assessed 5 consecutive days; from preoperative day up to third postoperative day. Both patients groups were similar preoperatively, except they had different number of coronary arteries affected. During and after surgery there were no serious complications like myocardial infarct or death. No patients required postoperative dialysis support. Four patients, which are 8 % of all patients included in the study, developed acute renal injury class Risk for injury by RIFLE classification. Two of them were operated with cardiopulmonary bypass and two without it. Patients operated with cardiopulmonary bypass developed statistically significant but subclinical reduced GFR. Patients operated without cardiopulmonary bypass had stable GFR after surgery and uninjured renal function. Reduced renal function (GFR) after surgery with cardiopulmonary bypass we demonstrated with serum creatinine, cystatin C and calculated estimation of GFR from both serum markers. Measured creatinine clearances were unreliable, mainly because of imprecise collecting of timed urine samples and they also overestimate GFR, because creatinine is also secreted in urine by renal tubules.

Jezik:Slovenski jezik
Ključne besede:Mur encimi inhibitorji inhibitorji encima MurC inhibitorji encima MurD sinteza protimikrobne učinkovine
Vrsta gradiva:Diplomsko delo (m5)
Tipologija:2.11 - Diplomsko delo
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2008
Založnik:[Cirkvenčič N.]
Št. strani:78 f.
UDK:542.057:543
COBISS.SI-ID:2335089 Povezava se odpre v novem oknu
Število ogledov:215
Število prenosov:62
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Sekundarni jezik

Jezik:Angleški jezik
Naslov:Design and synthesis of 2-amino-2-oxoethyl-N-(arylsulphonil)carbamates as MurC and MurD inhibitors
Izvleček:
After coronary artery bypass grafting, which are the most common types of cardiac surgery, develops acute renal injury requiring replacement therapy in 1–5 %. They are associated with high rates of morbidity and mortality. For this relevant clinical problem, it is recommended to monitor renal function after surgery. Standard parameters for investigating renal function in clinical routine are serum creatinine, measured creatinine clearance and in present time a prediction equation to estimate glomerular filtration rate (GFR) from serum creatinine by the MDRD study equation, but they all are based on measurement of serum creatinine, which is influenced by a lot of factors such as formation and excretion of creatinine and method of determination. In our study we included also a new marker of renal function serum cystatin C and predicted estimate GFR from serum cystatin C. We performed a prospective and partly randomized trial in 50 patients, half of the patients were operated on coronary arteries with cardiopulmonary bypass and the other half of patients were operated without cardiopulmonary bypass. Renal function was assessed 5 consecutive days; from preoperative day up to third postoperative day. Both patients groups were similar preoperatively, except they had different number of coronary arteries affected. During and after surgery there were no serious complications like myocardial infarct or death. No patients required postoperative dialysis support. Four patients, which are 8 % of all patients included in the study, developed acute renal injury class Risk for injury by RIFLE classification. Two of them were operated with cardiopulmonary bypass and two without it. Patients operated with cardiopulmonary bypass developed statistically significant but subclinical reduced GFR. Patients operated without cardiopulmonary bypass had stable GFR after surgery and uninjured renal function. Reduced renal function (GFR) after surgery with cardiopulmonary bypass we demonstrated with serum creatinine, cystatin C and calculated estimation of GFR from both serum markers. Measured creatinine clearances were unreliable, mainly because of imprecise collecting of timed urine samples and they also overestimate GFR, because creatinine is also secreted in urine by renal tubules.


Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj