Nonsteroidal anti-inflammatory drugs are one of the most commonly used drugs in the world. According to the composition, they are a diverse group of medicines, which are used for pain treatment, inflammation and fever. The most common side effects of nonsteroidal anti-inflammatory drugs manifest itself in the digestive system, but clinically very important and often overlooked are the deterioration of kidney disease, arterial hypertension, heart failure and liver cirrhosis. The thesis purpose was to retrospectively check the use of systematically applied nonsteroidal anti-inflammatory drugs with patients, aged 65 and older, who were treated in November 2015 in the surgical department of the General Hospital Novo mesto. We defined the prescribed anti-inflammatory drug’s suitability according to the indication, the level of disease, kidney function, simultaneous disease and simultaneous therapy. At suitability of prescribing medicine for elderly, we considered the Beers criteria, the START/STOP criteria and the Priscus list. Patients’ data, included in the research, will be acquired from their temperature’s lists, the Birpis programme and K22 programme for data’s analysis in the General Hospital Novo mesto. The study included 109 patients with an average age of 76 years. Ibuprofen was the most commonly prescribed drug, which is used orally and ketoprofen was applied intravenously. Beside nonsteroidal anti-inflammatory drugs, 86,2% of patients received an additional painkiller therapy, which was often a combination of paracetamol, tramadol and Na-metamizole. Nonsteroidal anti-inflammatory drugs were contraindicated with three patients according to the estimated speed of glomerular filtration. An extra caution with prescribing NSAID was needed with 17 patients according to the glomerular filtration’s speed. Regarding the estimated level of pain with visual analogue’s scale, the patients’ painkiller therapy was suitable in most cases. We focused on the simultaneous therapy which encompasses anti-hypertensives and drugs that affect blood coagulation. Anti-hypertensives prevailed, which is expected according to the fact that 68 patients had an arterial hypertension. Patients with anti-hypertensives in the therapy received different nonsteroidal anti-inflammatory drugs. We were not able to accurately assess whether this was appropriate or not, because we were unable to determine from the data whether hypertension is regulated or not. Medicines with an effect on blood coagulation were also very common, among antithrombotics, ASK prevailed (18 patients) and among anticoagulant, dalteparin prevailed (40 patients). These patients received a nonsteroidal anti-inflammatory drug the shortest time possible and in the lowest dose. According to the Priscus list, all nonsteroidal anti-inflammatory drugs were suitably prescribed. Prescribing was unsuitable with 15 patients according to the Beers criteria and with 52 patients according to the Start/Stop criteria.