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Načini zamreževanja TEMPO modificirane nanoceluloze za uporabo v dostavnih sistemih zdravil
ID Oman, Klemen (Author), ID Ručigaj, Aleš (Mentor) More about this mentor... This link opens in a new window

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Abstract
Nanoceluloza je material na osnovi celuloze, ki ima vsaj eno zmed svojih zunanjih dimenzij v nano območju. S svojo nizko težo, veliko trdnostjo in biokompatibilnostjo je v zadnjem času postala izredno zanimiva na številnih področjih. Uporablja se kot osnova v hidrogelih, ki se v farmacevtski industriji uporabljajo za tarčno in kontrolirano sproščanje učinkovin v telesu ter njihovo dostavo. Hidrogeli so v splošnem tridimenzionalna polimerna omrežja, ki lahko absorbirajo in zadržijo velike količine vode. Raziskovalci poskušajo lastnosti hidrogelov izboljšati z zamreževanjem. Ločimo fizikalno in kemijsko zamreženje. Fizikalno zamreženi hidrogeli nastanejo z medmolekulskimi reverzbilnimi interakcijami, medtem ko kemijsko zamreženi hidrogeli nastanejo preko kovalentnih vezi.

Language:Slovenian
Keywords:nanoceluloza, hidrogeli, zamreževanje, transportni sistemi zdravil
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2020
PID:20.500.12556/RUL-119690 This link opens in a new window
COBISS.SI-ID:31476739 This link opens in a new window
Publication date in RUL:10.09.2020
Views:1419
Downloads:172
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Secondary language

Language:English
Title:Crosslinking methods of TEMPO modified nanocellulose used in drug delivery
Abstract:
Nanocellulose is a cellulose-based material that has at least one of its external dimensions in the nano range. With its low weight, high strength and biocompatibility, it has recently become extremely interesting in many areas. It is used as a base in hydrogels, which are used in the pharmaceutical industry for targeted and controlled release of active substances in the body and their delivery. Hydrogels are generally three-dimensional polymer networks that can absorb and retain large amounts of water. Scientists are trying to improve the properties of hydrogels by crosslinking. We distinguish between physical and chemical crosslinking. Physically crosslinked hydrogels are formed by intramolecular reversible interactions, while chemically crosslinked hydrogels are formed through covalent bonds.

Keywords:nanocellulose, hydrogels, crosslinking, drug delivery systems

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