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Vpliv naravnih kanabinoidov na endokanabinoidni sistem in plodnost : diplomsko delo
ID Ribič, Eva (Avtor), ID Bagar, Tanja (Mentor) Več o mentorju... Povezava se odpre v novem oknu, ID Lepoša Korenjak, Sonja (Komentor), ID Mivšek, Ana Polona (Recenzent)

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Izvleček
Uvod: Za rabo v medicini je potrebno dobro proučiti delovanje kanabinoidov, njihov varnostni profil, prednosti in morebitne slabosti. Objavljenih je veliko tujih raziskav o vplivu endokanabinoidnega sistema in kanabinoidov na plodnost, prav tako pa je bilo narejenih že kar nekaj raziskav na področju uporabe kanabinoidov v namene zdravljenja. Kanabinoide lahko najdemo še v številnih drugih rastlinah poleg konoplje, ki pa vplivajo na naš endokanabinoidni sistem, ki uravnava naš hormonski sistem in vpliva na plodnost. Namen: Dokazati želimo pozitivne učinke uporabe kanabinoidov na plodnost pri moških, ženskah in samo zanositev pri ženskah. Namen je preučiti slovenske ter tuje raziskave o vplivu naravnih kanabinoidov (fitokanabinoidov) na človeški endokanabinoidni sistem, plodnost in možnost zanositve. Uporaba konoplje v medicini kot alternativa je trenutno zelo pereča tema in tudi izsledki te diplomske naloge bi lahko pripomogli do zaključkov o tem, kako uporabna oziroma škodljiva rastlina je konoplja. Metode dela: Uporabili smo deskriptivno metodo dela. Pregledali smo tujo in domačo literaturo s tematiko o vplivu kanabinoidov na reprodukcijo pri moških in ženskah. Baze, po katerih smo literaturo iskali, so bile PubMed, Medline, Cinahl in Cochrane. Konceptualni okvir diplomske naloge obsega pojme: kanabinoidi, endokanabinoidni sistem, plodnost, ženski reproduktivni sistem in konoplja. Kriteriji pri iskanju literature so bili starost literature manj kot 25 let, z izjemo ene, ki je iz leta 1986. Izbrana literatura je z vsebino o vplivu ter posledicah uporabe konoplje v času reprodukcije pri moških in ženskah in o vplivu na spočetje. Rezultati: Čeprav je na tem področju še veliko za raziskati, pa je že sedaj na voljo ogromno število znanstvenih publikacij na to temo. Nekatere študije ugotavljajo škodljive učinke kanabinoidov, spet druge pa pozitivne terapevtske učinke. Pomemben je način in cilj delovanja kanabinoidov, prepletanje delovanja endokanabinoidnega sistema in endokanabinoidov, hormonov in zunanjih dejavnikov, ki vplivajo na kakovost kanabinoidov. Pomembno je določanje točnih odmerkov in kombinacij za posameznika in poznavanje specifičnega mehanizma delovanja kanabinoidov. Razprava in zaključek: Na voljo je veliko raziskav in člankov. Nekateri ugotavljajo pozitivni, druge pa njen negativni vpliv na endokanabinoidni sistem in plodnost. Moramo se zavedati vpliva financerjev na rezultate, predvsem pa na interpretacijo rezultatov. Učinke na živalske organizme ne moremo enačiti z učinki, ki jih lahko ima konoplja na ljudi. Za utemeljeno rabo v medicini so potrebne nadaljnje študije o vplivu rastlinskih kanabinoidov na reprodukcijski sistem pri ljudeh. Ključne besede: kanabinoidi, ženski reproduktivni sistem, konoplja

Jezik:Slovenski jezik
Ključne besede:diplomska dela, babištvo, kanabinoidi, endokanabinoidni sistem, plodnost, ženski reproduktivni sistem, moški reproduktivni sistem, konoplja, uporaba v medicini
Vrsta gradiva:Diplomsko delo/naloga
Tipologija:2.11 - Diplomsko delo
Organizacija:ZF - Zdravstvena fakulteta
Kraj izida:Ljubljana
Založnik:[E. Ribič]
Leto izida:2020
Št. strani:47 str.
PID:20.500.12556/RUL-118146 Povezava se odpre v novem oknu
UDK:618.2/.7
COBISS.SI-ID:26025731 Povezava se odpre v novem oknu
Datum objave v RUL:23.08.2020
Število ogledov:1166
Število prenosov:236
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Sekundarni jezik

Jezik:Angleški jezik
Naslov:Effect of natural cannabinoids on endocannabinoid system and fertility : diploma work
Izvleček:
Introduction: For warranted use in medicine treatment we have to take a good look into activity of cannabinoids, their safety profile, advantages and eventual disadvantages. There is a lot of foreign researches about impact of endocannabinoid system and cannabinoids on fertility. Also a lot of researches were made about the use of cannabinoids in intentions of treatment. Cannabinoids can be found in many other plants, besides hemp, which have an influence on endocannabinoids system which is regulating hormonal system and have big impacts on fertility. Purpose: We want to show positive effects of using cannabinoids on fertility of male and female and conception of female. Our purpose is to examine Slovenian and fereign researches about impact of natural cannabinoids (phytocannabinoids) on human endocannabinoid's system, fertility and possibility of conception. Use of hemp in medicine and as an alternative is very popular theme at the moment and our findings could make a small conclusions about, how useful or harmful it is. Methods: We used descriptive method of work. We examined Slovenian and foreign literature about cannabinoids effects on fertility of male and female. Bases that we used for searching literature were PubMed, Medline, Cinahl and Cochrane. Conceptual frame of this diploma contains words such as: cannabinoids, endocannabinoid system, fertility, female reproduction system and hemp. Literature that was used in this diploma needed to be less than 25 years old with one exception which is from the year 1986. Used literature has a content about impact and consequences about hemp use during reproduction of male and female and impact on conception of female. Results: Although there is still a lot to look into, there is already enormous number of scientific publicitations about hemp and its impact on fertility and conception. Some studies identify the adverse effects of cannabinoids, while others identify potential therapeutic effects. Important is the way and the goal of cannabinoid action, the interplay of the endocannabinoid system and endocannabinoids, hormones and external factors that affect the quality of cannabinoids. It is important to determine the exact doses and combinations for individual organism and specific mechanism of cannabinoids functioning. Discussion and conclusion: Many researches and articles are available. Some of them talk about hemp advantages, others about hemp disadvantages on endocannabinoid system and fertility. We must keep in mind that the one who financed research has a huge impact on its final conclusions. The effects of cannabis on animals cannot be compare with the effects that cannabis can have on humans. For use of cannabis in medicine, we need further researches about influence of human's reproductive system. Key words: cannabinoids, female reproduction system, cannabis

Ključne besede:diploma theses, midwifery, cannabinoids, endocannabinoid system, fertility, female reproduction system, male reproduction, cannabis, medical use

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