Due to the increase in life expectancy, the prevalence of neurodegenerative diseases is increasing, however the pathogenesis of most of the neurodegenerative diseases remains unclear. Advances in gene editing technology, such as CRISPR/Cas, allows us to create cellular and animal models for neurodegenerative diseases in humans. This thesis gives an up-to-date overview of the already conducted research on neurodegenerative diseases and discusses the potential of CRISPR/Cas technology for the design of cellular and animal models that replicate pathology of human neurodegenerative diseases. Animal models are the key to obtaining important information about the course of the neurodegenerative diseases, possible treatments or the process of slowing down the progression of the disease.
|
