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Stem cells in veterinary medicine : current state and treatment options
Voga, Metka (Avtor), Adamič, Neža (Avtor), Vengušt, Modest (Avtor), Majdič, Gregor (Avtor)

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Izvleček
Regenerative medicine is a branch of medicine that develops methods to grow, repair, or replace damaged or diseased cells, organs or tissues. It has gained significant momentum in recent years. Stem cells are undifferentiated cells with the capability to self—renew and differentiate into tissue cells with specialized functions. Stem cell therapies are therefore used to overcome the body's inability to regenerate damaged tissues and metabolic processes after acute or chronic insult. The concept of stem cell therapy was first introduced in 1991 by Caplan, who proposed that massive differentiation of cells into the desired tissue could be achieved by isolation, cultivation, and expansion of stem cells in in vitro conditions. Among different stem cell types, mesenchymal stem cells (MSC) currently seem to be the most suitable for therapeutic purposes, based on their simple isolation and culturing techniques, and lack of ethical issues regarding their usage. Because of their remarkable immunomodulatory abilities, MSCs are increasingly gaining recognition in veterinary medicine. Developments are primarily driven by the limitations of current treatment options for various medical problems in different animal species. MSCs represent a possible therapeutic option for many animal diseases, such as orthopedic, orodental and digestive tract diseases, liver, renal, cardiac, respiratory, neuromuscular, dermal, olfactory, and reproductive system diseases. Although we are progressively gaining an understanding of MSC behavior and their mechanisms of action, some of the issues considering their use for therapy are yet to be resolved. The aim of this review is first to summarize the current knowledge and stress out major issues in stem cell based therapies in veterinary medicine and, secondly, to present results of clinical usage of stem cells in veterinary patients.

Jezik:Angleški jezik
Ključne besede:stem cells, clinical veterinary medicine, regenerative medicine, dogs, cats, horses
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:VF - Veterinarska fakulteta
Leto izida:2020
Št. strani:Str. 1-20
Številčenje:Vol. 7, art. 278
UDK:636.09:575
ISSN pri članku:2297-1769
DOI:10.3389/fvets.2020.00278 Povezava se odpre v novem oknu
COBISS.SI-ID:20242435 Povezava se odpre v novem oknu
Število ogledov:336
Število prenosov:138
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Frontiers in veterinary science
Skrajšan naslov:Front. vet. sci.
Založnik:Frontiers Media
ISSN:2297-1769
COBISS.SI-ID:3969402 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P4-0053
Naslov:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:22.06.2020

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