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Changes in local capillarity of pure and hybrid MyHC muscle fiber types after nerve injury in rat extensor digitorum longus muscle (EDL)
Čebašek, Vita (Avtor), Ribarič, Samo (Avtor)

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URLURL - Predstavitvena datoteka, za dostop obiščite https://www.ncbi.nlm.nih.gov/pubmed/31093775 Povezava se odpre v novem oknu
URLURL - Izvorni URL, za dostop obiščite https://link.springer.com/article/10.1007%2Fs00418-019-01787-3 Povezava se odpre v novem oknu

Izvleček
Recently, we evaluated capillary indices without discrimination by fiber type in rat extensor digitorum longus muscle (EDL) 4 weeks after nerve cut (NC), after double nerve crush (double NCR) and in two controls, from the start (CON-1) and the end (CON-2) of the experiment. In the present study, we determined the capillary indices related to specific myosin heavy chain (MyHC) fiber types. Fiber-type composition and local capillarity were assessed from a single, composite, multicolor image, where different MyHC-fiber types and capillaries were shown simultaneously. Applying local capillary indices [the number of capillaries around fiber (CAF) and the CAF scaled to fiber perimeter (CAF/FP)], to specific MyHC-fiber types, we found changes relevant to neuro-muscular studies. In the NC group, only type-2x fibers had a significantly lower CAF, and in the double NCR group, only type-2a fibers had a higher CAF in comparison with both controls. Both types of nerve injury elicited two responses: a coupled regulation of fiber size and capillarity in the oxidative, type 2a fibers and a capillarity independent regulation of fiber size in the glycolytic type-2b fibers. All subtypes of type-2 fibers had a better capillary supply (higher CAF/FP) in the NC and double NCR than in CON-2. The highest improvement was observed in type-2b fibers; this change was mirrored in an oxidative shift only in the double NCR group. Adopting fiber-type-specific capillary indices improves data analysis of rat EDL muscle samples.

Jezik:Angleški jezik
Ključne besede:capillary supply, fluorescence imaging, nerve injury
Vrsta gradiva:Članek v reviji (dk_c)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Leto izida:2019
Št. strani:str. 89-107
Številčenje:Vol. 152, iss. 2
UDK:616-092
ISSN pri članku:0948-6143
DOI:10.1007/s00418-019-01787-3 Povezava se odpre v novem oknu
COBISS.SI-ID:34311641 Povezava se odpre v novem oknu
Število ogledov:40
Število prenosov:29
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Histochemistry and cell biology
Založnik:Springer
ISSN:0948-6143
COBISS.SI-ID:1401876 Povezava se odpre v novem oknu

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P3-0043
Naslov:Molekularni mehanizmi razvoja in delovanja skeletne mišice

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P3-0171
Naslov:Plastičnost živčevja v fizioloških in patofizioloških razmerah

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:kapilarna oskrba, fluorescenčno slikanje, poškodbe živcev

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